Visceral adipogenesis inhibited by Pref-1 is associated with peritoneal angiogenesis.
Authors of this article are:
Jing R, Feng H, Jiang N, Zhang H, Fang W, Ni Z, Yuan J.
A summary of the article is shown below:
AIM: Studies showed an increased visceral adipose tissue and peritoneal angiogenesis in peritoneal dialysis (PD) patients. However, the relationship between the visceral adipose expands and peritoneal angiogenesis remains unclear.METHODS: Pref-1 (preadipocyte factor-1) recombinant adeno-associated virus (AAV) and control AAV were constructed. Mice were divided into 4 groups, mice in control and PD group were injected intraperitoneally with PBS, mice in control-AAV-PD and pref-1-AAV-PD group were injected with plaque-forming unit (PFU) control AAV and PFU recombinant AAV, respectively. Two weeks later, control group and other groups was injected intraperitoneally with normal saline and 4.25% peritoneal dialysis fluid (PDF) respectively. Visceral adipose tissue was collected and weighed. Pref-1 protein expression and peritoneal permeability as well as mesenteric blood vessel number and vascular endothelial growth factor (VEGF) in serum were measured.RESULTS: Pref-1 protein expression increased in pref-1-AAV-PD group. Visceral adipose expanded in PD and control-AAV-PD group while decreased in pref-1-AAV-PD group, which approves PDF enhance visceral adipogensis, and the process could be inhibited by Pref-1 recombinant AAV. The reduction of peritoneal vessel number and the decrease of vascular permeability as well as down-regulation of serum VEGF observed in pref-1-AAV-PD group suggested peritoneal angiogenesis could be inhibited following visceral adipose tissue reduction.CONCLUSION: Visceral adipose expands is associated with peritoneal angiogenesis in PD treatment, and prevention of visceral adipogenesis may be an alternative way to protect the validity of peritoneum. This article is protected by copyright. All rights reserved.This article is protected by copyright. All rights reserved.
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This article is a good source of information and a good way to become familiar with topics such as: adipogenesis; angiogenesis; peritoneal dialysis; preadipocyte factor-1.