The Predictive Value of Endpoint Quaking-Induced Conversion in Creutzfeldt-Jakob Disease.

A new interesting article has been published in Can J Neurol Sci. 2019 Jul 3:1-4. doi: 10.1017/cjn.2019.72. and titled:

The Predictive Value of Endpoint Quaking-Induced Conversion in Creutzfeldt-Jakob Disease.

Authors of this article are:

Budhram A, Taylor RG, Fuller J, Burneo JG, Knox JD, Pasternak SH.

A summary of the article is shown below:

Creutzfeldt-Jakob disease (CJD) is a fatal neurological illness for which accurate diagnosis is paramount. Real-time quaking-induced conversion (RT-QuIC) is a prion-specific assay with high sensitivity and specificity for CJD. The Canadian endpoint quaking-induced conversion (EP-QuIC) test is similar, but unlike RT-QuIC there is little data regarding its diagnostic utility in clinical practice. In this exploratory predictive value analysis of EP-QuIC in CJD, the negative predictive value (NPV) and positive predictive value (PPV) was 100% and 83%, respectively, with one false-positive result identified. Re-testing this sample with an optimized EP-QuIC protocol eliminated this false-positive result, leading to a PPV of 100%.

Check out the article’s website on Pubmed for more information:



This article is a good source of information and a good way to become familiar with topics such as: CJD;Creutzfeldt-Jakob disease;EP-QulC;Prion disease;Quaking-induced conversion;RT-QulC.

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