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A new interesting article has been published in Chem Pharm Bull (Tokyo). 2019 Jul 1;67(7):690-692. doi: 10.1248/cpb.c19-00240. Epub 2019 Apr 20. and titled:

Synthesis and Photodynamic Activity of Peri-xanthenoxanthene Derivatives.

Authors of this article are:

Chen Y, Li ZQ, Deng YQ, Yu BY, Pan WL, Song HC.

A summary of the article is shown below:

Photodynamic therapy (PDT) is a modern cancer therapy. But it is still difficult to obtain ideal photosensitizers. We synthesized six new peri-xanthenoxanthene derivatives rapidly and efficiently using solid-phase carbon-bath microwave irradiation technology, and investigated their in vitro photodynamic antitumor activity with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Our results showed that all compounds exhibited extremely low dark cytotoxicity and good phototoxicity against four human cancer cell lines. In particular, compound 3c showed the best in vitro PDT activity against Hela cells and Bel-7402 cells with IC50 values of 91 and 74 nmol/L, respectively. Its value of 1-octanol/water partition coefficient (log Kow) was 0.5309, suggesting that it is a promising photosensitizer for PDT due to its low dark cytotoxicity, high phototoxicity, and potential water solubility.

Check out the article’s website on Pubmed for more information:

[link-preview url=https://www.ncbi.nlm.nih.gov/pubmed/31006721 forceshot=true]

This article is a good source of information and a good way to become familiar with topics such as: Cell Line, Tumor;Cell Survival;Drug Screening Assays, Antitumor;HeLa Cells;Humans;Inhibitory Concentration 50;Microwaves;Neoplasms;Photochemotherapy;Photosensitizing Agents;Reactive Oxygen Species;Xanthenes.

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