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A new interesting article has been published in Mult Scler Relat Disord. 2019 Jul;32:27-29. doi: 10.1016/j.msard.2019.04.021. Epub 2019 Apr 15. and titled:

Successful intravenous immunoglobulin treatment in relapsing MOG-antibody-associated disease.

Authors of this article are:

Tsantes E, Curti E, Siena E, Granella F.

A summary of the article is shown below:

Treatment of MOG Ab-associated disease is poorly standardized: several drugs have been employed, with variable results. A 50-year-old Caucasian male was admitted to hospital in 2009, with severe acute transverse myelitis. A brain and spinal cord MRI showed multiple demyelinating lesions and cerebrospinal fluid analysis revealed no oligoclonal bands (OCBs). A diagnosis of multiple sclerosis (MS) was made. He was treated with interferon-beta 1a, then with fingolimod, and finally with rituximab. All these treatments were ineffective: he experienced several spinal and brainstem relapses, with residual disability. Finally, an empirical therapy with IVIg was started. Calling into question the diagnosis of MS, we performed anti-MOG test (positive). IVIg therapy was continued and the patient experienced only one mild relapse during a 24-month follow-up. Our patient, with an aggressive and atypical MOG Ab-associated disease, showed a very good response to longterm IVIg treatment.Copyright © 2019. Published by Elsevier B.V.

Check out the article’s website on Pubmed for more information:

[link-preview url=https://www.ncbi.nlm.nih.gov/pubmed/31026608 forceshot=true]

This article is a good source of information and a good way to become familiar with topics such as: Demyelination;Immunoglobulin;MOG-antibody-associated disease;Neuroinflammation.

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