Transcriptional regulation of Bcl-2 gene by the PR/SET domain family member PRDM10.

A new interesting article has been published in PeerJ. 2019 May 15;7:e6941. doi: 10.7717/peerj.6941. eCollection 2019. and titled:

Transcriptional regulation of Bcl-2 gene by the PR/SET domain family member PRDM10.

Authors of this article are:

Chen N, Hu T, Gui Y, Gao J, Li Z, Huang S.

A summary of the article is shown below:

Bcl-2 (B-cell lymphoma 2) protein is localized in the outer membrane of mitochondria, where it plays an important role in promoting cellular survival and inhibiting the actions of pro-apoptotic proteins. PRDM10 is a member of the PR/SET family of epigenetic regulators and may play a role in development and cell differentiation. Here we show that human PRDM10 contributes to the transcriptional regulation of human Bcl-2 gene. We found that PRDM10-depletion in human cells reduced the expression of Bcl-2 protein and over-expression of PRDM10 promoted Bcl-2 protein expression. Furthermore, luciferase reporter activity of Bcl-2 gene P1 promoter was significantly increased in cells co-transfected with PRDM10, and PRDM10 was able to bind to the Bcl-2 P1 promoter in vivo. Using The Cancer Genome Atlas (TCGA) data set, we found weak positive correlation between PRDM10 and Bcl-2 in several cancer types including cancers of the breast, colon, and lung tissues. These data identify a novel function for PRDM10 protein and provide insights on the transcriptional control of Bcl-2 expression.

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This article is a good source of information and a good way to become familiar with topics such as: B-cell lymphoma-2; Bcl-2; PRDM10 protein; The Cancer Genome Atlas; Transcription.