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A new interesting article has been published in Laryngoscope. 2019 Aug;129(8):1828-1835. doi: 10.1002/lary.27634. Epub 2018 Dec 24. and titled:

Risk and outcomes for second primary human papillomavirus-related and -unrelated head and neck malignancy.

Authors of this article are:

Adjei Boakye E, Buchanan P, Hinyard L, Stamatakis K, Osazuwa-Peters N, Simpson MC, Schootman M, Piccirillo JF.

A summary of the article is shown below:

OBJECTIVES/HYPOTHESIS: To 1) examine the characteristics of patients who develop second primary malignancies (SPMs) from an index human papillomavirus (HPV)-related head and neck squamous cell carcinoma (HNSCC) and HPV-unrelated HNSCC and to 2) compare overall survival between those with HPV-related and HPV-unrelated index HNSCC among patients who develop SPM.STUDY DESIGN: Retrospective cohort analysis.METHODS: A retrospective study was conducted of 113,259 patients who were diagnosed with HNSCC from 2000 to 2014. SPM was defined as the first subsequent primary cancer occurring at least 2 months after index cancer diagnosis, and HPV-relatedness was based on whether patients’ index HNSCC was potentially HPV-related or HPV-unrelated. Multivariable Fine and Gray (FG) competing-risks regression models were used to estimate factors associated with risk of SPM by HPV-relatedness. Among patients with SPM, an adjusted Cox proportional hazards (PH) regression model was used to assess the association between HPV-relatedness and survival.RESULTS: Approximately 13,900 patients (12.3%) developed SPM. In the FG model, patients with HPV-unrelated HNSCC had a 15% higher risk of developing SPM (adjusted hazard ratio: 1.15, 95% confidence interval: 1.10-1.20) than those with potentially HPV-related HNSCC, but the same characteristics were associated with SPM development. In the Cox PH model, patients with SPM whose index HNSCC was HPV-unrelated had higher risk of death than those whose index HNSCC was potentially HPV-related (adjusted hazard ratio: 1.06; 95% confidence interval: 1.02-1.11).CONCLUSIONS: Patients with HPV-unrelated HNSCC have a higher risk of SPM development than do those with HPV-related HNSCC. Effective secondary disease-prevention strategies should be established to improve long-term patient outcomes.LEVEL OF EVIDENCE: NA Laryngoscope, 129:1828-1835, 2019.© 2018 The American Laryngological, Rhinological and Otological Society, Inc.

Check out the article’s website on Pubmed for more information:

[link-preview url=https://www.ncbi.nlm.nih.gov/pubmed/30582167 forceshot=true]

This article is a good source of information and a good way to become familiar with topics such as: Epidemiology;Head and neck squamous cell carcinoma;Surveillance;and End Results (SEER);human papillomavirus;risk factor;second primary malignancy;survival.

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