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A new interesting article has been published in Expert Opin Drug Saf. 2019 Jul;18(7):603-610. doi: 10.1080/14740338.2019.1617272. Epub 2019 May 20. Review and titled:

Occurrence of hepatocellular carcinoma after direct-acting antiviral therapy for hepatitis C virus infection: literature review and risk analysis.

Authors of this article are:

Galati G, Muley M, Viganò M, Iavarone M, Vitale A, Dell’Unto C, Lai Q, Cabibbo G, Sacco R, Villa E, Trevisani F.

A summary of the article is shown below:

INTRODUCTION: Concerns were raised about a high occurrence of hepatocellular carcinoma (HCC) after successful treatment of chronic hepatitis C (CHC) by direct-acting antivirals (DAAs).AREAS COVERED: The authors summarize the clinical studies reporting the occurrence rate and risk factors of HCC after DAAs in CHC.EXPERT OPINION: The recent introduction of all-oral DAAs has substantially changed the scenario of CHC, achieving a sustained virological response (SVR) in >90% of cases. Earlier concerns raised about an increasing incidence of HCC post-DAAs were flawed by large heterogeneity of patients, the limited number of well-designed prospective studies (only nine, up to date) and the inclusion of a large number of patients with advanced liver disease, previously excluded from interferon-based studies. Current data on DAAs have shown a lower risk of HCC development; however, they were unable to identify patients at greater risk for HCC occurrence after SVR. Surveillance strategy, likely lifelong, is mandatory in these patients according to general expert opinion.

Check out the article’s website on Pubmed for more information:

[link-preview url=https://www.ncbi.nlm.nih.gov/pubmed/31067134 forceshot=true]

This article is a good source of information and a good way to become familiar with topics such as: Antiviral Agents;Carcinoma, Hepatocellular;Hepatitis C, Chronic;Humans;Incidence;Liver Neoplasms;Research Design;Risk Factors;Sustained Virologic Response;Treatment Outcome.

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