Human Recombinant B7-H4

Product Description

Human Recombinant B7-H4
Catalog number: B2017003
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 50 µg
Molecular Weight or Concentration: 52.3 kDa
Supplied as: Powder
Applications: a molecular tool for various biochemical applications
Storage: -80°C
Keywords: B7 Homolog 4, B7h.5, B7S1, B7x, Immune Costimulatory Protein B7-H4, PRO1291, V-set Domain-containing T cell Activation Inhibitor 1, VCTN1
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Kinneer K, Wortmann P, Cooper ZA, Dickinson NJ, Masterson L, Cailleau T, Hutchinson I, Vijayakrishnan B, McFarlane M, Ball K, Davies M, Lewis A, Huang Y, Rosenbaum AI, Yuan J, Chesebrough J, Anderton J, Monks N, Novick S, Wang J, Dimasi N, Christie RJ, Sabol D, Tosto FA, Wallez Y, Leo E, Albertella MR, Staniszewska AD, Tice DA, Howard PW, Luheshi N, Sapra P. Design and Preclinical Evaluation of a Novel B7-H4-Directed Antibody-Drug Conjugate, AZD8205, Alone and in Combination with the PARP1-Selective Inhibitor AZD5305 Clin Cancer Res. 2023 Mar 14;29(6):1086-1101.
2: Dangaj D, Lanitis E, Zhao A, Joshi S, Cheng Y, Sandaltzopoulos R, Ra HJ, Danet-Desnoyers G, Powell DJ Jr, Scholler N. Novel recombinant human b7-h4 antibodies overcome tumoral immune escape to potentiate T-cell antitumor responses Cancer Res. 2013 Aug 1;73(15):4820-9.
3: Mao YX, Chen YJ, Ge Y, Ma HB, Yu JF, Wu HY, Hu YM, Wang Q, Shi Q, Zhang XG. Recombinant human B7-H4 expressed in Escherichia coli inhibits T lymphocyte proliferation and IL-2 secretion in vitro Acta Pharmacol Sin. 2006 Jun;27(6):741-6.
4: Wang X, Wang T, Xu M, Xiao L, Luo Y, Huang W, Zhang Y, Geng W. B7-H4 overexpression impairs the immune response of T cells in human cervical carcinomas Hum Immunol. 2014 Dec;75(12):1203-9.
5: Ji H, Guo J, Yang Y, Xu C, Mao W. Construction, expression and functional analysis of anti-B7-H4- scFv-CH3 recombinant antibody J Biosci. 2018 Sep;43(4):661-671.
6: Cheng L, Jiang J, Gao R, Wei S, Nan F, Li S, Kong B. B7-H4 expression promotes tumorigenesis in ovarian cancer Int J Gynecol Cancer. 2009 Dec;19(9):1481-6.
7: Hong B, Qian Y, Zhang H, Sang YW, Cheng LF, Wang Q, Gao S, Zheng M, Yao HP. Expression of B7-H4 and hepatitis B virus X in hepatitis B virus-related hepatocellular carcinoma World J Gastroenterol. 2016 May 14;22(18):4538-46.
8: Ou D, Wang X, Metzger DL, Ao Z, Pozzilli P, James RF, Chen L, Warnock GL. Suppression of human T-cell responses to beta-cells by activation of B7-H4 pathway Cell Transplant. 2006;15(5):399-410.
9: Yuan L, Ye J, Fan D. The B7-H4 gene induces immune escape partly via upregulating the PD-1/Stat3 pathway in non-small cell lung cancer Hum Immunol. 2020 May;81(5):254-261.
10: Shao L, Xu C, Ji H, Mao W, Wang Y, Liu X, Zhu Y. [Construction of anti-B7-H4-scFv library and screening and identification of anti-B7-H4-scFv] Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2016 Sep;32(9):1260-6.

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