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Human Myeloperoxidase (MPO) Native

Original price was: $1,995.00.Current price is: $995.00.

Catalog Number: B2016962 (50 µg)
Human Myeloperoxidase (MPO) Native is a high quality enzyme found in human neutrophils, which are a type of white blood cell. MPO plays a key role in the immune system by producing hypochlorous acid and other reactive oxygen species to help kill pathogens such as bacteria and fungi. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

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Product Description

Human Myeloperoxidase (MPO) Native
Catalog number: B2016962
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 50 µg
Molecular Weight or Concentration: 130,000 – 150,000 Da
Supplied as: Powder
Applications: a molecular tool for various biochemical applications
Storage: -80°C
Keywords: Human Myeloperoxidase (MPO) Native
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Erdbrügger U, Hellmark T, Bunch DO, Alcorta DA, Jennette JC, Falk RJ, Nachman PH. Mapping of myeloperoxidase epitopes recognized by MPO-ANCA using human-mouse MPO chimers Kidney Int. 2006 May;69(10):1799-805.
2: Audrain MA, Baranger TA, Moguilevski N, Martin SJ, Devys A, Lockwood CM, Muller JY, Esnault VL. Anti-native and recombinant myeloperoxidase monoclonals and human autoantibodies Clin Exp Immunol. 1997 Jan;107(1):127-34.
3: Frangie C, Daher J. Role of myeloperoxidase in inflammation and atherosclerosis (Review) Biomed Rep. 2022 Jun;16(6):53.
4: Zhao L, Shen C, Xie S, Zhou J, Zhang H, Zhu H, Li Y, Gao S. The role and mechanism of myeloperoxidase in dermatomyositis Int Immunopharmacol. 2023 Nov;124(Pt A):110803.
5: Krawczyk L, Semwal S, Soubhye J, Lemri Ouadriri S, Prévost M, Van Antwerpen P, Roos G, Bouckaert J. Native glycosylation and binding of the antidepressant paroxetine in a low-resolution crystal structure of human myeloperoxidase Acta Crystallogr D Struct Biol. 2022 Sep 1;78(Pt 9):1099-1109.
6: Arnhold J, Furtmüller PG, Obinger C. Redox properties of myeloperoxidase Redox Rep. 2003;8(4):179-86.
7: Falk RJ, Becker M, Terrell R, Jennette JC. Anti-myeloperoxidase autoantibodies react with native but not denatured myeloperoxidase Clin Exp Immunol. 1992 Aug;89(2):274-8.
8: Cao Z, Cheng G. Recombinant Myeloperoxidase as a New Class of Antimicrobial Agents Microbiol Spectr. 2022 Feb 23;10(1):e0052221.
9: Dufour D, Khalil A, Nuyens V, Rousseau A, Delporte C, Noyon C, Cortese M, Reyé F, Pireaux V, Nève J, Vanhamme L, Robaye B, Lelubre C, Desmet JM, Raes M, Boudjeltia KZ, Van Antwerpen P. Native and myeloperoxidase-oxidized low-density lipoproteins act in synergy to induce release of resolvin-D1 from endothelial cells Atherosclerosis. 2018 May;272:108-117.
10: Boomsma MM, Stegeman CA, Oost-Kort WW, Kallenberg CG, Moguilevsky N, Limburg PC, Tervaert JW. Native and recombinant proteins to analyze auto-antibodies to myeloperoxidase in pauci-immune crescentic glomerulonephritis J Immunol Methods. 2001 Aug 1;254(1-2):47-58.

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Additional Information

Weight 48 oz
Dimensions 8 × 8 × 8 in

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