ALKBH1 Protein

Product Description

ALKBH1 Protein
Catalog number: B2016684
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 25 µg
Molecular Weight or Concentration: 47.6 kDa
Supplied as: Solution
Applications: a molecular tool for various biochemical applications
Storage: -80°C
Keywords: AlkB Homolog 1, Histone H2A Dioxygenase
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Ougland R, Jonson I, Moen MN, Nesse G, Asker G, Klungland A, Larsen E. Role of ALKBH1 in the Core Transcriptional Network of Embryonic Stem Cells Cell Physiol Biochem. 2016;38(1):173-84.
2: Ougland R, Lando D, Jonson I, Dahl JA, Moen MN, Nordstrand LM, Rognes T, Lee JT, Klungland A, Kouzarides T, Larsen E. ALKBH1 is a histone H2A dioxygenase involved in neural differentiation Stem Cells. 2012 Dec;30(12):2672-82.
3: Müller TA, Yu K, Hausinger RP, Meek K. ALKBH1 is dispensable for abasic site cleavage during base excision repair and class switch recombination PLoS One. 2013 Jun 25;8(6):e67403.
4: Müller TA, Struble SL, Meek K, Hausinger RP. Characterization of human AlkB homolog 1 produced in mammalian cells and demonstration of mitochondrial dysfunction in ALKBH1-deficient cells Biochem Biophys Res Commun. 2018 Jan 1;495(1):98-103.
5: Müller TA, Tobar MA, Perian MN, Hausinger RP. Biochemical Characterization of AP Lyase and m(6)A Demethylase Activities of Human AlkB Homologue 1 (ALKBH1) Biochemistry. 2017 Apr 4;56(13):1899-1910.
6: Krokan HE, Kavli B, Slupphaug G. Novel aspects of macromolecular repair and relationship to human disease J Mol Med (Berl). 2004 May;82(5):280-97.
7: Drabløs F, Feyzi E, Aas PA, Vaagbø CB, Kavli B, Bratlie MS, Peña-Diaz J, Otterlei M, Slupphaug G, Krokan HE. Alkylation damage in DNA and RNA–repair mechanisms and medical significance DNA Repair (Amst). 2004 Nov 2;3(11):1389-407.
8: Zdżalik D, Vågbø CB, Kirpekar F, Davydova E, Puścian A, Maciejewska AM, Krokan HE, Klungland A, Tudek B, van den Born E, Falnes PØ. Protozoan ALKBH8 oxygenases display both DNA repair and tRNA modification activities PLoS One. 2014 Jun 10;9(6):e98729.
9: Shimada K, Nakamura M, Anai S, De Velasco M, Tanaka M, Tsujikawa K, Ouji Y, Konishi N. A novel human AlkB homologue, ALKBH8, contributes to human bladder cancer progression Cancer Res. 2009 Apr 1;69(7):3157-64.
10: Lee DH, Jin SG, Cai S, Chen Y, Pfeifer GP, O’Connor TR. Repair of methylation damage in DNA and RNA by mammalian AlkB homologues J Biol Chem. 2005 Nov 25;280(47):39448-59.

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