6-acryloyl-2-dimethylaminonaphthalene (Acrylodan)


Catalog Number: B2011221 (2 mg)
6-acryloyl-2-dimethylaminonaphthalene (Acrylodan) is a high quality thiol-reactive dye sensitive to proteins conformational changes . This product has been used as molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

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6-acryloyl-2-dimethylaminonaphthalene (Acrylodan)
Catalog number: B2011221
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 2 mg
Molecular Weight or Concentration: 225.3 g/mol
Supplied as: Lyophilized
Applications: molecular tool for various biochemical applications
Storage: -20 °C
Keywords: 6-acryloyl-2-dimethylaminonaphthalene
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

1: Svensson R, Grenö C, Johansson AS, Mannervik B, Morgenstern R. Synthesis and characterization of 6-chloroacetyl-2-dimethylaminonaphthalene as a fluorogenic substrate and a mechanistic probe for glutathione transferases Anal Biochem. 2002 Dec 15;311(2):171-8.
2: Prendergast FG, Meyer M, Carlson GL, Iida S, Potter JD. Synthesis, spectral properties, and use of 6-acryloyl-2-dimethylaminonaphthalene (Acrylodan). A thiol-selective, polarity-sensitive fluorescent probe J Biol Chem. 1983 Jun 25;258(12):7541-4.
3: Graceffa P. Hsp27-actin interaction Biochem Res Int. 2011;2011:901572.
4: Reid SW, Koepf EK, Burtnick LD. Fluorescent responses of acrylodan-labeled plasma gelsolin Arch Biochem Biophys. 1993 Apr;302(1):31-6.
5: Simard JR, Kamp F, Hamilton JA. Acrylodan-labeled intestinal fatty acid-binding protein to measure concentrations of unbound fatty acids Methods Mol Biol. 2007;400:27-43.
6: Fruen BR, Balog EM, Schafer J, Nitu FR, Thomas DD, Cornea RL. Direct detection of calmodulin tuning by ryanodine receptor channel targets using a Ca2+-sensitive acrylodan-labeled calmodulin Biochemistry. 2005 Jan 11;44(1):278-84.
7: Hickey JM, Sahni N, Chaudhuri R, D’Souza A, Metters A, Joshi SB, Russell Middaugh C, Volkin DB. Effect of acrylodan conjugation and forced oxidation on the structural integrity, conformational stability, and binding activity of a glucose binding protein SM4 used in a prototype continuous glucose monitor Protein Sci. 2017 Mar;26(3):527-535.
8: Brunaldi K, Simard JR, Kamp F, Rewal C, Asawakarn T, O’Shea P, Hamilton JA. Fluorescence assays for measuring fatty acid binding and transport through membranes Methods Mol Biol. 2007;400:237-55.
9: Fung HYJ, McKibben KM, Ramirez J, Gupta K, Rhoades E. Structural Characterization of Tau in Fuzzy Tau:Tubulin Complexes Structure. 2020 Mar 3;28(3):378-384.e4.
10: Acosta D, Das T, Eliezer D. Probing IDP Interactions with Membranes by Fluorescence Spectroscopy Methods Mol Biol. 2020;2141:555-567.

Products Related to 6-acryloyl-2-dimethylaminonaphthalene (Acrylodan) can be found at Dyes

Additional information

Weight 48 oz
Dimensions 8 × 8 × 8 in

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