The inflammatory response to a wheelchair half-marathon in people with a spinal cord injury – the role of autonomic function.
Authors of this article are:
Hoekstra SP, Leicht CA, Kamijo YI, Kinoshita T, Stephenson BT, Goosey-Tolfrey VL, Bishop NC, Tajima F.
A summary of the article is shown below:
This study investigates the relationship between autonomic function and the inflammatory response to a wheelchair half-marathon in people with a spinal cord injury (SCI). Seventeen wheelchair athletes with a cervical SCI (CSCI, N = 7) and without CSCI (NON-CSCI, N = 10) participated in a wheelchair half-marathon. Blood was taken prior, post and 1 h post-race to determine the concentrations of adrenaline, noradrenaline, extracellular heat shock protein 72 (eHsp72) and interleukin-6 (IL-6). A sit-up tilt test was performed to assess autonomic function at rest. CSCI showed a lower supine ratio of the low and high frequency power of the variability in RR intervals (LF/HF RRI, p = 0.038), total and low frequency power of the systolic blood pressure variability (TP SBP, p < 0.001; LF SBP, p = 0.005) compared to NON-CSCI. Following the race, catecholamine concentrations increased only in NON-CSCI (p < 0.036). The increase in IL-6 post-race was larger in NON-CSCI (p = 0.040). Post-race catecholamine levels explained 60% of the variance in the IL-6 response (r = 0.77, p = 0.040), which was further increased when the resting autonomic function indices were added to the regression model (R2 > 81%, p < 0.012). In summary, the dampened acute inflammatory response to a wheelchair half-marathon in CSCI was strongly associated with the autonomic dysfunction present in this group.
Check out the article’s website on Pubmed for more information:
This article is a good source of information and a good way to become familiar with topics such as: Adult;Autonomic Nervous System;Blood Pressure;Epinephrine;HSP72 Heat-Shock Proteins;Heart Rate;Humans;Inflammation;Male;Middle Aged;Norepinephrine;Receptors, Interleukin-6;Spinal Cord Injuries;Sports for Persons with Disabilities;Tilt-Table Test;Upper Extremity;Wheelchairs.
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