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A new interesting article has been published in J Cancer Res Clin Oncol. 2019 Jul;145(7):1823-1833. doi: 10.1007/s00432-019-02904-4. Epub 2019 Mar 29. and titled:

Predicting the risk of locoregional recurrence after early breast cancer: an external validation of the Dutch INFLUENCE-nomogram with clinical canc…

Authors of this article are:

Voelkel V, Draeger T, Groothuis-Oudshoorn CGM, de Munck L, Hueting T, Gerken M, Klinkhammer-Schalke M, Lavric M, Siesling S.

A summary of the article is shown below:

PURPOSE: Follow-up after breast cancer treatment aims for an early detection of locoregional breast cancer recurrences (LRR) to improve the patients’ outcome. By estimating individual’s 5-year recurrence-risks, the Dutch INFLUENCE-nomogram can assist health professionals and patients in developing personalized risk-based follow-up pathways. The objective of this study is to validate the prediction tool on non-Dutch patients.MATERIAL AND METHODS: Data for this external validation derive from a large clinical cancer registry in southern Germany, covering a population of 1.1 million. Patients with curative resection of early-stage breast cancer, diagnosed between 2000 and 2012, were included in the analysis (n = 6520). For each of them, an individual LRR-risk was estimated by the INFLUENCE-nomogram. Its predictive ability was tested by comparing estimated and observed LRR-probabilities using the Hosmer-Lemeshow goodness-of-fit test and C-statistics.RESULTS: In the German validation-cohort, 2.8% of the patients developed an LRR within 5 years after primary surgery (n = 184). While the INFLUENCE-nomogram generally underestimates the actual LRR-risk of the German patients (p < 0.001), its discriminative ability is comparable to the one observed in the original Dutch modeling-cohort (C-statistic German validation-cohort: 0.73, CI 0.69-0.77 vs. C-statistic Dutch modeling-cohort: 0.71, CI 0.69-0.73). Similar results were obtained in most of the subgroup analyses stratified by age, type of surgery and intrinsic biological subtypes.CONCLUSION: The outcomes of this external validation underline the generalizability of the INFLUENCE-nomogram beyond the Dutch population. The model performance could be enhanced in future by incorporating additional risk factors for LRR.
Check out the article’s website on Pubmed for more information:

[link-preview url=https://www.ncbi.nlm.nih.gov/pubmed/30927074 forceshot=true]

This article is a good source of information and a good way to become familiar with topics such as: Aged;Breast Neoplasms;Cohort Studies;Female;Germany;Humans;Middle Aged;Neoplasm Recurrence, Local;Netherlands;Registries;Reproducibility of Results.

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