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A new interesting article has been published in Maturitas. 2019 Jul;125:5-10. doi: 10.1016/j.maturitas.2019.03.015. Epub 2019 Mar 31. and titled:

Plasma total testosterone and risk of incident atrial fibrillation: The Atherosclerosis Risk in Communities (ARIC) study.

Authors of this article are:

Berger D, Folsom AR, Schreiner PJ, Chen LY, Michos ED, O’Neal WT, Soliman EZ, Alonso A.

A summary of the article is shown below:

OBJECTIVE: Whether endogenous testosterone concentrations are associated with atrial fibrillation (AF) development is not well established. We assessed the association between plasma total testosterone concentrations and incident AF in a population-based longitudinal study.STUDY DESIGN: Using data from the prospective Atherosclerosis Risk in Communities (ARIC) study, we identified incident AF among 9282 participants who had plasma total testosterone measured by liquid chromatography tandem mass spectrometry at Visit 4 (1996-1998).MAIN OUTCOME MEASURES: AF cases were identified by electrocardiograms performed during study visits, hospital records/discharge codes, and death certificates through 2013. We estimated hazard ratios (HRs) and 95% confidence intervals (95% CIs) for incident AF across quartiles of plasma total testosterone, stratified by sex, with multivariable Cox models.RESULTS: The mean age of the participant sample at ARIC Visit 4 was 63 years (range 52-75); 54.5% were women. Mean (SD) plasma total testosterone levels were 537 ng/dL (213) for men and 27.6 ng/dL (34.7) for women. Over a mean of 13.7 years of follow-up, 1664 incident cases of AF were identified. Comparing those in the highest quartile of plasma total testosterone concentration to those in the lowest quartile and after adjustment for potential confounding variables, there was a positive association between plasma total testosterone and incident AF in men (HR 1.33, 95% CI 1.07, 1.66), but no such association in women (HR 0.99, 95% CI 0.80, 1.22). Conclusion A higher plasma total testosterone concentration was associated with a modestly greater incidence rate of AF in men.Copyright © 2019 Elsevier B.V. All rights reserved.

Check out the article’s website on Pubmed for more information:

[link-preview url=https://www.ncbi.nlm.nih.gov/pubmed/31133217 forceshot=true]

This article is a good source of information and a good way to become familiar with topics such as: Aged;Atherosclerosis;Atrial Fibrillation;Electrocardiography;Female;Glomerular Filtration Rate;Humans;Incidence;Longitudinal Studies;Male;Middle Aged;Proportional Hazards Models;Prospective Studies;Risk Factors;Sex Factors;Testosterone.

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