Relaxin-2 (Human)

Description

Relaxin-2 (Human)
Catalog number: MDP0858
CAS Number: 332837-02-2
Sequence: A-chain: Pyr-Leu-Tyr-Ser-Ala-Leu-Ala-Asn-Lys-Cys-Cys-His-Val-Gly-Cys-Thr-Lys-Arg-Ser-Leu-Ala-Arg-Phe-Cys B-chain: Asp-Ser-Trp-Met-Glu-Glu-Val-Ile-Lys-Leu-Cys-Gly-Arg-Glu-Leu-Val-Arg-Ala-Gln-Ile-Ala-Ile-Cys-Gly-Met-Ser-Thr-Trp-Ser (Disulfide bonds between CysA10-CysA15, CysA11-CysB11, and CysA24-CysB23)
Amount: 50 ug
Molecular Weight: 5962.8 g/mol
Supplied as: Powder
Applications: molecular tool for various biochemical applications
Storage: -20 °C
WARNING: For in vitro Research Use Only. NOT for use on humans or animals.
Grade: Biotechnology grade. All products are highly pure.

References:
1: Stewart DR. Commercial immunoassays for human relaxin-2 Mol Cell Endocrinol. 2019 May 1;487:94-97.
2: Nair VB, Samuel CS, Separovic F, Hossain MA, Wade JD. Human relaxin-2: historical perspectives and role in cancer biology Amino Acids. 2012 Sep;43(3):1131-40.
3: Yang M, Li J, Gu P, Fan X. The application of nanoparticles in cancer immunotherapy: Targeting tumor microenvironment Bioact Mater. 2020 Dec 26;6(7):1973-1987.
4: Hossain MA, Wade JD. The roles of the A- and B-chains of human relaxin-2 and -3 on their biological activity Curr Protein Pept Sci. 2010 Dec;11(8):719-24.
5: Lee KC, Hsieh YC, Chan CC, Sun HJ, Huang YH, Hou MC, Lin HC. Human relaxin-2 attenuates hepatic steatosis and fibrosis in mice with non-alcoholic fatty liver disease Lab Invest. 2019 Jul;99(8):1203-1216.
6: Dschietzig TB. Recombinant human relaxin-2: (how) can a pregnancy hormone save lives in acute heart failure? Am J Cardiovasc Drugs. 2014 Oct;14(5):343-55.
7: Kwok WH, Choi TLS, Leung GNW, Wong ASY, Yue SK, Wan TSM, Ho ENM. Administration study of recombinant human relaxin-2 in horse for doping control purpose Drug Test Anal. 2020 Mar;12(3):361-370.
8: Sun J, Hao W, Fillmore N, Ma H, Springer D, Yu ZX, Sadowska A, Garcia A, Chen R, Muniz-Medina V, Rosenthal K, Lin J, Kuruvilla D, Osbourn J, Karathanasis SK, Walker J, Murphy E. Human Relaxin-2 Fusion Protein Treatment Prevents and Reverses Isoproterenol-Induced Hypertrophy and Fibrosis in Mouse Heart J Am Heart Assoc. 2019 Dec 17;8(24):e013465.
9: Ma J, Niu M, Yang W, Zang L, Xi Y. Role of relaxin-2 in human primary osteosarcoma Cancer Cell Int. 2013 Jun 10;13(1):59.
10: Wolf VL, Phillips TL, Taylor EB, Sasser JM, Ryan MJ. Human recombinant relaxin-2 does not attenuate hypertension or renal injury but exacerbates vascular dysfunction in a female mouse model of SLE Am J Physiol Heart Circ Physiol. 2019 Aug 1;317(2):H234-H242.

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