Recombinant Human FLT3 Ligand Protein

Product Description

Recombinant Human FLT3 Ligand Protein
Catalog number: B2015674
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 10 μg
Molecular Weight or Concentration: 23 to 30 kDa, monomer, glycosylated
Supplied as: Powder
Applications: a molecular tool for various biochemical applications
Storage: -20 °C
Keywords: FL, Flt3 ligand, Flt3L, FLT3LG, SL cytokine
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Zhang D, Guo Y, Zhao Y, Yu L, Chang Z, Pei H, Huang J, Chen C, Xue H, Xu X, Pan Y, Li N, Zhu C, Zhao ZJ, Yu J, Chen Y. Expression of a recombinant FLT3 ligand and its emtansine conjugate as a therapeutic candidate against acute myeloid leukemia cells with FLT3 expression Microb Cell Fact. 2021 Mar 10;20(1):67.
2: Verstraete K, Koch S, Ertugrul S, Vandenberghe I, Aerts M, Vandriessche G, Thiede C, Savvides SN. Efficient production of bioactive recombinant human Flt3 ligand in E. coli Protein J. 2009 Feb;28(2):57-65.
3: Drexler HG. Expression of FLT3 receptor and response to FLT3 ligand by leukemic cells Leukemia. 1996 Apr;10(4):588-99.
4: Dehmel U, Zaborski M, Meierhoff G, Rosnet O, Birnbaum D, Ludwig WD, Quentmeier H, Drexler HG. Effects of FLT3 ligand on human leukemia cells. I. Proliferative response of myeloid leukemia cells Leukemia. 1996 Feb;10(2):261-70.
5: Spagnoli GC, Kloth J, Terracciano L, Trutmann M, Chklovskaia E, Remmel E, Noppen C, Zajac P, Kocher T, Heberer M. FLT3 ligand gene expression and protein production in human colorectal cancer cell lines and clinical tumor specimens Int J Cancer. 2000 Apr 15;86(2):238-43.
6: Verstraete K, Remmerie B, Elegheert J, Lintermans B, Haegeman G, Vanhoenacker P, Van Craenenbroeck K, Savvides SN. Inducible production of recombinant human Flt3 ectodomain variants in mammalian cells and preliminary crystallographic analysis of Flt3 ligand-receptor complexes Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Mar 1;67(Pt 3):325-31.
7: Heiss E, Masson K, Sundberg C, Pedersen M, Sun J, Bengtsson S, Rönnstrand L. Identification of Y589 and Y599 in the juxtamembrane domain of Flt3 as ligand-induced autophosphorylation sites involved in binding of Src family kinases and the protein tyrosine phosphatase SHP2 Blood. 2006 Sep 1;108(5):1542-50.
8: McKenna HJ, de Vries P, Brasel K, Lyman SD, Williams DE. Effect of flt3 ligand on the ex vivo expansion of human CD34+ hematopoietic progenitor cells Blood. 1995 Nov 1;86(9):3413-20.
9: Zurkova K, Hainz P, Krystofova J, Kutinova L, Sanda M, Nemeckova S. Attenuation of vaccinia virus by the expression of human Flt3 ligand Virol J. 2010 May 26;7:109.
10: Xu ZX, Xu Y, Zhu JK, Li CX, Li Y, Zhang XG. Effects of dexamethasone on Flt3 receptor expression and proliferation induced by recombinant human Flt3 ligand in malignant hematopoietic cells Acta Pharmacol Sin. 2001 Jun;22(6):534-40.

Products Related to Recombinant Human FLT3 Ligand Protein can be found at Proteins