Notch3 Antibody Monoclonal

Product Description

Notch3 Antibody Monoclonal
Catalog number: B2010597
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 200 uL
Molecular Weight or Concentration: na
Supplied as: Solution
Applications: molecular tool in the study of Notch 3
Storage: -20C
Keywords: Monoclonal Anti-Notch3 antibody produced in rat, Anti-CADASIL, Anti-CASIL, anti-notch3 antibody
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Yu J, Siebel CW, Schilling L, Canalis E. An antibody to Notch3 reverses the
skeletal phenotype of lateral meningocele syndrome in male mice. J Cell Physiol.
2020 Jan;235(1):210-220.

2: Katoh M, Katoh M. Precision medicine for human cancers with Notch signaling
dysregulation (Review). Int J Mol Med. 2020 Feb;45(2):279-297.
3: Varga J, Nicolas A, Petrocelli V, Pesic M, Mahmoud A, Michels BE, Etlioglu E,
Yepes D, Häupl B, Ziegler PK, Bankov K, Wild PJ, Wanninger S, Medyouf H, Farin
HF, Tejpar S, Oellerich T, Ruland J, Siebel CW, Greten FR. AKT-dependent NOTCH3
activation drives tumor progression in a model of mesenchymal colorectal cancer.
J Exp Med. 2020 Oct 5;217(10):e20191515.

4: Young KZ, Lee SJ, Zhang X, Cartee NMP, Torres M, Keep SG, Gabbireddy SR,
Fontana JL, Qi L, Wang MM. NOTCH3 is non-enzymatically fragmented in inherited
cerebral small-vessel disease. J Biol Chem. 2020 Feb 14;295(7):1960-1972.

5: Machuca-Parra AI, Bigger-Allen AA, Sanchez AV, Boutabla A, Cardona-Vélez J,
Amarnani D, Saint-Geniez M, Siebel CW, Kim LA, D’Amore PA, Arboleda-Velasquez
JF. Therapeutic antibody targeting of Notch3 signaling prevents mural cell loss
in CADASIL. J Exp Med. 2017 Aug 7;214(8):2271-2282.

6: Rosen LS, Wesolowski R, Baffa R, Liao KH, Hua SY, Gibson BL, Pirie-Shepherd
S, Tolcher AW. A phase I, dose-escalation study of PF-06650808, an anti-Notch3
antibody-drug conjugate, in patients with breast cancer and other advanced solid
tumors. Invest New Drugs. 2020 Feb;38(1):120-130.

7: Ghezali L, Capone C, Baron-Menguy C, Ratelade J, Christensen S, Østergaard
Pedersen L, Domenga-Denier V, Pedersen JT, Joutel A. Notch3^ECD
immunotherapy improves cerebrovascular responses in CADASIL mice. Ann Neurol.
2018 Aug;84(2):246-259.

8: Geles KG, Gao Y, Giannakou A, Sridharan L, Yamin TT, Zhang J, Karim R, Bard
J, Piche-Nicholas N, Charati M, Maderna A, Lucas J, Golas J, Guffroy M, Pirie-
Shepherd S, Roy M, Qian J, Franks T, Zhong W, O’Donnell CJ, Tchistiakova L,
Gerber HP, Sapra P. NOTCH3-targeted antibody drug conjugates regress tumors by
inducing apoptosis in receptor cells and through transendocytosis into ligand
cells. Cell Rep Med. 2021 May 18;2(5):100279.

9: Lu H, Jiang Z. Advances in antibody therapeutics targeting small-cell lung
cancer. Adv Clin Exp Med. 2018 Sep;27(9):1317-1323.
10: Wu D, Zhang P, Ma J, Xu J, Yang L, Xu W, Que H, Chen M, Xu H. Serum
biomarker panels for the diagnosis of gastric cancer. Cancer Med. 2019
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