Human WISP-1 (Highly Pure Recombinant)
Catalog Number: B2010376 (10 ug)
Human WISP-1 (Highly Pure) is a high quality research product used as highly pure Human WISP-1 (Highly Pure) expressed in CHO. This protein acts as a WNT-inducible secreted protein that promotes angiogenesis in cancers. Custom bulk orders of this product are available upon request.
Human WISP-1 (Highly Pure)
Catalog number: B2010376
Lot number: Batch Dependent
Expiration Date: Batch dependent
Volume/Weight: 10 ug
pH: 7.4 upon reconstitution
Supplied as: Lyophilized Powder
Applications: highly pure Human WISP-1 (Highly Pure) expressed in CHO. This protein acts as a WNT-inducible secreted protein that promotes angiogenesis in cancers.
Keywords: rHuWISP-1; WNT1-inducible-signaling pathway protein 1; CCN4
Grade: Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.
1: Meyers CA, Xu J, Asatrian G, Ding C, Shen J, Broderick K, Ting K, Soo C,
Peault B, James AW. WISP-1 drives bone formation at the expense of fat formation
in human perivascular stem cells. Sci Rep. 2018 Oct 23;8(1):15618.
2: Tsai HC, Tzeng HE, Huang CY, Huang YL, Tsai CH, Wang SW, Wang PC, Chang AC,
Fong YC, Tang CH. WISP-1 positively regulates angiogenesis by controlling VEGF-A
expression in human osteosarcoma. Cell Death Dis. 2017 Apr 13;8(4):e2750.
3: Chang AC, Chen PC, Lin YF, Su CM, Liu JF, Lin TH, Chuang SM, Tang CH.
Osteoblast-secreted WISP-1 promotes adherence of prostate cancer cells to bone
via the VCAM-1/integrin α4β1 system. Cancer Lett. 2018 Jul 10;426:47-56.
4: Li FJ, Wang XJ, Zhou XL. WISP-1 overexpression upregulates cell proliferation
in human salivary gland carcinomas via regulating MMP-2 expression. Onco Targets
Ther. 2016 Oct 21;9:6539-6548.
5: Hou CH, Chiang YC, Fong YC, Tang CH. WISP-1 increases MMP-2 expression and
cell motility in human chondrosarcoma cells. Biochem Pharmacol. 2011 Jun
6: Quiros M, Nishio H, Neumann PA, Siuda D, Brazil JC, Azcutia V, Hilgarth R,
O’Leary MN, Garcia-Hernandez V, Leoni G, Feng M, Bernal G, Williams H, Dedhia
PH, Gerner-Smidt C, Spence J, Parkos CA, Denning TL, Nusrat A. Macrophage-
derived IL-10 mediates mucosal repair by epithelial WISP-1 signaling. J Clin
Invest. 2017 Sep 1;127(9):3510-3520.
7: Lin CC, Chen PC, Lein MY, Tsao CW, Huang CC, Wang SW, Tang CH, Tung KC.
WISP-1 promotes VEGF-C-dependent lymphangiogenesis by inhibiting miR-300 in
human oral squamous cell carcinoma cells. Oncotarget. 2016 Mar
8: Wright LH, Herr DJ, Brown SS, Kasiganesan H, Menick DR. Angiokine Wisp-1 is
increased in myocardial infarction and regulates cardiac endothelial signaling.
JCI Insight. 2018 Feb 22;3(4):e95824.
9: Kovács B, Vajda E, Nagy EE. Regulatory Effects and Interactions of the Wnt
and OPG-RANKL-RANK Signaling at the Bone-Cartilage Interface in Osteoarthritis.
Int J Mol Sci. 2019 Sep 19;20(18):4653.
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