Human Recombinant IDO1

Product Description

Human Recombinant IDO1
Catalog number: B2016936
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 25 µg
Molecular Weight or Concentration: 46 kDa
Supplied as: Solution
Applications: a molecular tool for various biochemical applications
Storage: -80°C
Keywords: Indoleamine 2,3-dioxygenase 1, Indoleamine-pyrrole 2,3-dioxygenase
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Yang SL, Tan HX, Niu TT, Liu YK, Gu CJ, Li DJ, Li MQ, Wang HY. The IFN-γ-IDO1-kynureine pathway-induced autophagy in cervical cancer cell promotes phagocytosis of macrophage Int J Biol Sci. 2021 Jan 1;17(1):339-352.
2: Saimi D, Wang Z, Zhu Q, Lv J. Expression, purification, and kinetic characterization of the human strep-IDO1 Transl Cancer Res. 2022 May;11(5):993-1004.
3: Cheng AN, Cheng LC, Kuo CL, Lo YK, Chou HY, Chen CH, Wang YH, Chuang TH, Cheng SJ, Lee AY. Mitochondrial Lon-induced mtDNA leakage contributes to PD-L1-mediated immunoescape via STING-IFN signaling and extracellular vesicles J Immunother Cancer. 2020 Dec;8(2):e001372.
4: Bellucci M, Pompa A, De Marcos Lousa C, Panfili E, Orecchini E, Maricchiolo E, Fraternale D, Orabona C, De Marchis F, Pallotta MT. Human Indoleamine 2,3-dioxygenase 1 (IDO1) Expressed in Plant Cells Induces Kynurenine Production Int J Mol Sci. 2021 May 12;22(10):5102.
5: Zheng Z, Guo X, Yu M, Wang X, Lu H, Li F, Wang J. Identification of Human IDO1 Enzyme Activity by Using Genetically Encoded Nitrotyrosine Chembiochem. 2020 Jun 2;21(11):1593-1596.
6: Lee J, Jang J, Cha SR, Lee SB, Hong SH, Bae HS, Lee YJ, Yang SR. Recombinant Human Bone Morphogenetic Protein-2 Priming of Mesenchymal Stem Cells Ameliorate Acute Lung Injury by Inducing Regulatory T Cells Immune Netw. 2023 Dec 18;23(6):e48.
7: Lou Q, Liu R, Yang X, Li W, Huang L, Wei L, Tan H, Xiang N, Chan K, Chen J, Liu H. miR-448 targets IDO1 and regulates CD8(+) T cell response in human colon cancer J Immunother Cancer. 2019 Aug 7;7(1):210.
8: Tijono SM, Palmer BD, Tomek P, Flanagan JU, Henare K, Gamage S, Braun L, Ching LM. Evaluation of Novel Inhibitors of Tryptophan Dioxygenases for Enzyme and Species Selectivity Using Engineered Tumour Cell Lines Expressing Either Murine or Human IDO1 or TDO2 Pharmaceuticals (Basel). 2022 Aug 31;15(9):1090.
9: Pol J, Bloy N, Buqué A, Eggermont A, Cremer I, Sautès-Fridman C, Galon J, Tartour E, Zitvogel L, Kroemer G, Galluzzi L. Trial Watch: Peptide-based anticancer vaccines Oncoimmunology. 2015 Jan 9;4(4):e974411.
10: Arkhypov I, Özbay Kurt FG, Bitsch R, Novak D, Petrova V, Lasser S, Hielscher T, Groth C, Lepper A, Hu X, Li W, Utikal J, Altevogt P, Umansky V. HSP90α induces immunosuppressive myeloid cells in melanoma via TLR4 signaling J Immunother Cancer. 2022 Sep;10(9):e005551.

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