Human Recombinant Follistatin

Product Description

Human Recombinant Follistatin
Catalog number: B2016938
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 25 µg
Molecular Weight or Concentration: 61.7 kDa
Supplied as: Powder
Applications: a molecular tool for various biochemical applications
Storage: -80°C
Keywords: Activin-binding Protein, FS, FSH-suppressing Protein, FST
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Iyer S, Zhang S, Yucel S, Horn H, Smith SG, Reinhardt F, Hoefsmit E, Assatova B, Casado J, Meinsohn MC, Barrasa MI, Bell GW, Pérez-Villatoro F, Huhtinen K, Hynninen J, Oikkonen J, Galhenage PM, Pathania S, Hammond PT, Neel BG, Farkkila A, Pépin D, Weinberg RA. Genetically Defined Syngeneic Mouse Models of Ovarian Cancer as Tools for the Discovery of Combination Immunotherapy Cancer Discov. 2021 Feb;11(2):384-407.
2: Li W, Khorasheh S, Yuen BH, Ling N, Leung PC. Stimulation of progesterone secretion by recombinant follistatin-288 in human granulosa cells Endocrinology. 1993 Apr;132(4):1750-6.
3: Shen C, Iskenderian A, Lundberg D, He T, Palmieri K, Crooker R, Deng Q, Traylor M, Gu S, Rong H, Ehmann D, Pescatore B, Strack-Logue B, Romashko A, Baviello G, Gill J, Zhang B, Meiyappan M, Pan C, Norton AW. Protein Engineering on Human Recombinant Follistatin: Enhancing Pharmacokinetic Characteristics for Therapeutic Application J Pharmacol Exp Ther. 2018 Aug;366(2):291-302.
4: Wong KS, Cheung HW, Choi YC, To NS, Wan TSM, Ho ENM. Screening and confirmation of recombinant human follistatin in equine plasma for doping control purposes Drug Test Anal. 2024 Mar;16(3):259-267.
5: Nguyen HQ, Iskenderian A, Ehmann D, Jasper P, Zhang Z, Rong H, Welty D, Narayanan R. Leveraging Quantitative Systems Pharmacology Approach into Development of Human Recombinant Follistatin Fusion Protein for Duchenne Muscular Dystrophy CPT Pharmacometrics Syst Pharmacol. 2020 Jun;9(6):342-352.
6: Li W, Alahdal M, Deng Z, Liu J, Zhao Z, Cheng X, Chen X, Li J, Yin J, Li Y, Wang G, Wang D, Tang K, Zhang J. Molecular functions of FSTL1 in the osteoarthritis Int Immunopharmacol. 2020 Jun;83:106465.
7: Inouye S, Guo Y, DePaolo L, Shimonaka M, Ling N, Shimasaki S. Recombinant expression of human follistatin with 315 and 288 amino acids: chemical and biological comparison with native porcine follistatin Endocrinology. 1991 Aug;129(2):815-22.
8: Tilbrook AJ, Clarke IJ, de Kretser DM. Human recombinant follistatin-288 suppresses plasma concentrations of follicle-stimulating hormone but is not a significant regulator of luteinizing hormone in castrated rams Biol Reprod. 1995 Dec;53(6):1353-8.
9: Li W, Zhang L, Yin X, Ai H. The Effects of Follistatin on the Differentiation of Human Bone Marrow Mesenchymal Stem Cells into Neurons-Like Cells Ann Clin Lab Sci. 2020 Jan;50(1):3-12.
10: Inouye S, Guo Y, Ling N, Shimasaki S. Site-specific mutagenesis of human follistatin Biochem Biophys Res Commun. 1991 Aug 30;179(1):352-8.

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