Human Platelet Factor 4 Native

Product Description

Human Platelet Factor 4 Native
Catalog number: B2016964
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 10 μg
Molecular Weight or Concentration: 27.1 kDa homotetramer (7.8 kDa subunits)
Supplied as: Powder
Applications: a molecular tool for various biochemical applications
Storage: -80°C
Keywords: Platelet factor 4, C-X-C motif chemokine 4, CXCL4, Iroplact, Oncostatin-A, SCYB4
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Li N. Platelets as an inter-player between hyperlipidaemia and atherosclerosis J Intern Med. 2024 Jul;296(1):39-52.
2: Gewirtz AM, Calabretta B, Rucinski B, Niewiarowski S, Xu WY. Inhibition of human megakaryocytopoiesis in vitro by platelet factor 4 (PF4) and a synthetic COOH-terminal PF4 peptide J Clin Invest. 1989 May;83(5):1477-86.
3: Niu C, Yang Y, Huynh A, Nazy I, Kaltashov IA. Platelet Factor 4 Interactions with Short Heparin Oligomers: Implications for Folding and Assembly Biophys J. 2020 Oct 6;119(7):1371-1379.
4: Ataei S, Taheri MN, Tamaddon G, Behzad-Behbahani A, Taheri F, Rahimi A, Zare F, Amirian N. High-yield production of recombinant platelet factor 4 by harnessing and honing the gram-negative bacterial secretory apparatus PLoS One. 2020 May 7;15(5):e0232661.
5: Rucinski B, Niewiarowski S, Strzyzewski M, Holt JC, Mayo KH. Human platelet factor 4 and its C-terminal peptides: heparin binding and clearance from the circulation Thromb Haemost. 1990 Jun 28;63(3):493-8.
6: Foss B, Ulvestad E, Bruserud Ø. Platelet-derived growth factor (PDGF) in human acute myelogenous leukemia: PDGF receptor expression, endogenous PDGF release and responsiveness to exogenous PDGF isoforms by in vitro cultured acute myelogenous leukemia blasts Eur J Haematol. 2001 Oct;67(4):267-78.
7: Park KS, Rifat S, Eck H, Adachi K, Surrey S, Poncz M. Biologic and biochemic properties of recombinant platelet factor 4 demonstrate identity with the native protein Blood. 1990 Mar 15;75(6):1290-5.
8: Han Z, Shen Q, Han Z. [Bioassay of recombinant human platelet factor 4] Zhonghua Xue Ye Xue Za Zhi. 1997 Mar;18(3):123-5.
9: St Charles R, Walz DA, Edwards BF. The three-dimensional structure of bovine platelet factor 4 at 3.0-A resolution J Biol Chem. 1989 Feb 5;264(4):2092-9.
10: Foss B, Ulvestad E, Bruserud O. Platelet-derived growth factor (PDGF) in human acute myelogenous leukemia: PDGF receptor expression, endogenous PDGF release and responsiveness to exogenous PDGF isoforms by in vitro cultured acute myelogenous leukemia blasts Eur J Haematol. 2001 Jun;66(6):365-76.

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