Human Eotaxin/CCL11 (Recombinant)

Description

Human Eotaxin/CCL11
Catalog number: B2010353
Lot number: Batch Dependent
Expiration Date: Batch dependent
Volume/Weight: 10 ug
pH: 7.4 upon reconstitution
Supplied as: Lyophilized Powder
Appearance: Powder
Applications: highly pure Human Eotaxin/CCL11 expressed in E. coli. This protein acts as a potent chemoattractant for eosinophil cells and provides a new mechanism for tissue eosinophilia.
Storage: -20C
Keywords: rHuEotaxin/CCL11; C-C motif chemokine 11; Eosinophil chemotactic protein; SCYA11
Grade: Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Mangieri D, Corradi D, Martorana D, Malerba G, Palmisano A, Libri I, Bartoli
V, Carnevali ML, Goldoni M, Govoni P, Alinovi R, Buzio C, Vaglio A.
Eotaxin/CCL11 in idiopathic retroperitoneal fibrosis. Nephrol Dial Transplant.
2012 Oct;27(10):3875-84.

2: Cheng SS, Lukacs NW, Kunkel SL. Eotaxin/CCL11 is a negative regulator of
neutrophil recruitment in a murine model of endotoxemia. Exp Mol Pathol. 2002
Aug;73(1):1-8.

3: Cheng SS, Lukacs NW, Kunkel SL. Eotaxin/CCL11 suppresses IL-8/CXCL8 secretion
from human dermal microvascular endothelial cells. J Immunol. 2002 Mar
15;168(6):2887-94.

4: Zweifel M, Matozan K, Dahinden C, Schaffner T, Mohacsi P. Eotaxin/CCL11
levels correlate with myocardial fibrosis and mast cell density in native and
transplanted rat hearts. Transplant Proc. 2010 Sep;42(7):2763-6.

5: Pham TH, Damera G, Newbold P, Ranade K. Reductions in eosinophil biomarkers
by benralizumab in patients with asthma. Respir Med. 2016 Feb;111:21-9.

6: Zweifel M, Mueller C, Schaffner T, Dahinden C, Matozan K, Driscoll R, Mohacsi
P. Eotaxin/CCL11 expression by infiltrating macrophages in rat heart transplants
during ongoing acute rejection. Exp Mol Pathol. 2009 Oct;87(2):127-32.

7: Puxeddu I, Bader R, Piliponsky AM, Reich R, Levi-Schaffer F, Berkman N. The
CC chemokine eotaxin/CCL11 has a selective profibrogenic effect on human lung
fibroblasts. J Allergy Clin Immunol. 2006 Jan;117(1):103-10.

8: Schuh JM, Blease K, Kunkel SL, Hogaboam CM. Eotaxin/CCL11 is involved in
acute, but not chronic, allergic airway responses to Aspergillus fumigatus. Am J
Physiol Lung Cell Mol Physiol. 2002 Jul;283(1):L198-204.

9: Panizzutti B, Gubert C, Schuh AL, Ferrari P, Bristot G, Fries GR, Massuda R,
Walz J, Rocha NP, Berk M, Teixeira AL, Gama CS. Increased serum levels of
eotaxin/CCL11 in late-stage patients with bipolar disorder: An accelerated aging
biomarker? J Affect Disord. 2015 Aug 15;182:64-9.
10: Kohan M, Puxeddu I, Reich R, Levi-Schaffer F, Berkman N. Eotaxin-2/CCL24 and
eotaxin-3/CCL26 exert differential profibrogenic effects on human lung
fibroblasts. Ann Allergy Asthma Immunol. 2010 Jan;104(1):66-72.

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