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Human Desert Hedgehog (Highly Pure)

$695.00 $495.00

Catalog Number: B2010378 (10 ug)
Human Desert Hedgehog is a high quality research product used as highly pure Human Desert Hedgehog expressed in E. coli. This protein acts as a member of the Hedgehog family which encodes signaling molecules that play an important role in regulating morphogenesis. Custom bulk orders of this product are available upon request.

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SKU: B2010378 Categories: , ,

Description

Human Desert Hedgehog
Catalog number: B2010378
Lot number: Batch Dependent
Expiration Date: Batch dependent
Volume/Weight: 10 ug
pH: 7.4 upon reconstitution
Supplied as: Lyophilized Powder
Appearance: Powder
Applications: highly pure Human Desert Hedgehog expressed in E. coli. This protein acts as a member of the Hedgehog family which encodes signaling molecules that play an important role in regulating morphogenesis.
Storage: -20C
Keywords: rHuDHH; DHH; HHG-3
Grade: Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Sasai N, Toriyama M, Kondo T. Hedgehog Signal and Genetic Disorders. Front
Genet. 2019 Nov 8;10:1103.

2: Skoda AM, Simovic D, Karin V, Kardum V, Vranic S, Serman L. The role of the
Hedgehog signaling pathway in cancer: A comprehensive review. Bosn J Basic Med
Sci. 2018 Feb 20;18(1):8-20.

3: In JG, Yin J, Atanga R, Doucet M, Cole RN, DeVine L, Donowitz M, Zachos NC,
Blutt SE, Estes MK, Kovbasnjuk O. Epithelial WNT2B and Desert Hedgehog Are
Necessary for Human Colonoid Regeneration after Bacterial Cytotoxin Injury.
iScience. 2020 Sep 28;23(10):101618.

4: Chen H, Wang Y, Ge R, Zirkin BR. Leydig cell stem cells: Identification,
proliferation and differentiation. Mol Cell Endocrinol. 2017 Apr 15;445:65-73.

5: Zhu G, Zhau HE, He H, Zhang L, Shehata B, Wang X, Cerwinka WH, Elmore J, He
D. Sonic and desert hedgehog signaling in human fetal prostate development.
Prostate. 2007 May 1;67(6):674-84.

6: Chapouly C, Hollier PL, Guimbal S, Cornuault L, Gadeau AP, Renault MA. Desert
Hedgehog-Driven Endothelium Integrity Is Enhanced by Gas1 (Growth Arrest-
Specific 1) but Negatively Regulated by Cdon (Cell Adhesion Molecule-
Related/Downregulated by Oncogenes). Arterioscler Thromb Vasc Biol. 2020
Dec;40(12):e336-e349.

7: Queiroz KC, Tio RA, Zeebregts CJ, Bijlsma MF, Zijlstra F, Badlou B, de Vries
M, Ferreira CV, Spek CA, Peppelenbosch MP, Rezaee F. Human plasma very low
density lipoprotein carries Indian hedgehog. J Proteome Res. 2010 Nov
5;9(11):6052-9.

8: Kawabata N, Ijiri K, Ishidou Y, Yamamoto T, Nagao H, Nagano S, Maeda S,
Komiya S, Setoguchi T. Pharmacological inhibition of the Hedgehog pathway
prevents human rhabdomyosarcoma cell growth. Int J Oncol. 2011
Oct;39(4):899-906.
9: Azzi S, Treps L, Leclair HM, Ngo HM, Harford-Wright E, Gavard J. Desert
Hedgehog/Patch2 Axis Contributes to Vascular Permeability and Angiogenesis in
Glioblastoma. Front Pharmacol. 2015 Nov 24;6:281.

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