Human BHMT Protein

Description

Human BHMT Protein
Catalog number: B2011599
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 100 µg
Molecular Weight or Concentration: 1 mg/mL
Supplied as: Solution
Applications: molecular tool for various biochemical applications
Storage: -20 °C
Keywords: EC 2.1.1.5 protein, Betaine homocysteine S methyltransferase protein, Betaine–homocysteine S-methyltransferase 1 protein, , BHMT protein, BHMT1 protein, Betaine homocysteine S methyltransferase 1 protein, Betaine-homocysteine methyltransferase Betaine ho, BHMT protein (His tag)
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Wei W, Riley NM, Yang AC, Kim JT, Terrell SM, Li VL, Garcia-Contreras M, Bertozzi CR, Long JZ. Cell type-selective secretome profiling in vivo Nat Chem Biol. 2021 Mar;17(3):326-334.
2: Zeisel S. Choline, Other Methyl-Donors and Epigenetics Nutrients. 2017 Apr 29;9(5):445.
3: Pellanda H. Betaine homocysteine methyltransferase (BHMT)-dependent remethylation pathway in human healthy and tumoral liver Clin Chem Lab Med. 2013 Mar 1;51(3):617-21.
4: Frau M, Feo F, Pascale RM. Pleiotropic effects of methionine adenosyltransferases deregulation as determinants of liver cancer progression and prognosis J Hepatol. 2013 Oct;59(4):830-41.
5: Li F, Feng Q, Lee C, Wang S, Pelleymounter LL, Moon I, Eckloff BW, Wieben ED, Schaid DJ, Yee V, Weinshilboum RM. Human betaine-homocysteine methyltransferase (BHMT) and BHMT2: common gene sequence variation and functional characterization Mol Genet Metab. 2008 Jul;94(3):326-35.
6: Sternbach S, West N, Singhal NK, Clements R, Basu S, Tripathi A, Dutta R, Freeman EJ, McDonough J. The BHMT-betaine methylation pathway epigenetically modulates oligodendrocyte maturation PLoS One. 2021 May 11;16(5):e0250486.
7: Shen X, Zhang Y, Zhang X, Yao Y, Zheng Y, Cui X, Liu C, Wang Q, Li JZ. Long non-coding RNA Bhmt-AS attenuates hepatic gluconeogenesis via modulation of Bhmt expression Biochem Biophys Res Commun. 2019 Aug 13;516(1):215-221.
8: Li D, Yang J, Zhao Q, Zhang C, Ren B, Yue L, Du B, Godfrey O, Huang X, Zhang W. Genetic and epigenetic regulation of BHMT is associated with folate therapy efficacy in hyperhomocysteinaemia Asia Pac J Clin Nutr. 2019;28(4):879-887.
9: Feng Q, Kalari K, Fridley BL, Jenkins G, Ji Y, Abo R, Hebbring S, Zhang J, Nye MD, Leeder JS, Weinshilboum RM. Betaine-homocysteine methyltransferase: human liver genotype-phenotype correlation Mol Genet Metab. 2011 Feb;102(2):126-33.
10: Rui YN, Xu Z, Chen Z, Zhang S. The GST-BHMT assay reveals a distinct mechanism underlying proteasome inhibition-induced macroautophagy in mammalian cells Autophagy. 2015;11(5):812-32.

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