Human BEST1 Protein


Catalog Number: B2011605 (100 µg)
Human BEST1 Protein is a high quality recombinant human BEST1 protein His tagged and expressed in E. coli. This product has been used as molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

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Human BEST1 Protein
Catalog number: B2011605
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 100 µg
Molecular Weight or Concentration: 1 mg/mL
Supplied as: Solution
Applications: molecular tool for various biochemical applications
Storage: -20 °C
Keywords: Bestrophin-1 isoform 1 protein, ARB protein, BEST protein, BMD protein, RP50 protein, TU15B protein, VMD2 protein
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

1: Johnson AA, Guziewicz KE, Lee CJ, Kalathur RC, Pulido JS, Marmorstein LY, Marmorstein AD. Bestrophin 1 and retinal disease Prog Retin Eye Res. 2017 May;58:45-69.
2: Fahim AT, Daiger SP, Weleber RG. Nonsyndromic Retinitis Pigmentosa Overview 2000 Aug 4 [updated 2017 Jan 19]. In: Adam MP, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews(®) [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2022.
3: Birtel J, Eisenberger T, Gliem M, Müller PL, Herrmann P, Betz C, Zahnleiter D, Neuhaus C, Lenzner S, Holz FG, Mangold E, Bolz HJ, Charbel Issa P. Clinical and genetic characteristics of 251 consecutive patients with macular and cone/cone-rod dystrophy Sci Rep. 2018 Mar 19;8(1):4824.
4: Hazim RA, Volland S, Yen A, Burgess BL, Williams DS. Rapid differentiation of the human RPE cell line, ARPE-19, induced by nicotinamide Exp Eye Res. 2019 Feb;179:18-24.
5: Maggi J, Koller S, Bähr L, Feil S, Kivrak Pfiffner F, Hanson JVM, Maspoli A, Gerth-Kahlert C, Berger W. Long-Range PCR-Based NGS Applications to Diagnose Mendelian Retinal Diseases Int J Mol Sci. 2021 Feb 3;22(4):1508.
6: Oh SJ, Lee CJ. Distribution and Function of the Bestrophin-1 (Best1) Channel in the Brain Exp Neurobiol. 2017 Jun;26(3):113-121.
7: Doumanov JA, Zeitz C, Dominguez Gimenez P, Audo I, Krishna A, Alfano G, Diaz ML, Moskova-Doumanova V, Lancelot ME, Sahel JA, Nandrot EF, Bhattacharya SS. Disease-causing mutations in BEST1 gene are associated with altered sorting of bestrophin-1 protein Int J Mol Sci. 2013 Jul 22;14(7):15121-40.
8: Kittredge A, Zhang Y, Yang T. Evaluating BEST1 mutations in pluripotent stem cell-derived retinal pigment epithelial cells Methods Enzymol. 2021;654:365-382.
9: Milenkovic A, Milenkovic VM, Wetzel CH, Weber BHF. BEST1 protein stability and degradation pathways differ between autosomal dominant Best disease and autosomal recessive bestrophinopathy accounting for the distinct retinal phenotypes Hum Mol Genet. 2018 May 1;27(9):1630-1641.
10: Jo S, Yarishkin O, Hwang YJ, Chun YE, Park M, Woo DH, Bae JY, Kim T, Lee J, Chun H, Park HJ, Lee DY, Hong J, Kim HY, Oh SJ, Park SJ, Lee H, Yoon BE, Kim Y, Jeong Y, Shim I, Bae YC, Cho J, Kowall NW, Ryu H, Hwang E, Kim D, Lee CJ. GABA from reactive astrocytes impairs memory in mouse models of Alzheimer’s disease Nat Med. 2014 Aug;20(8):886-96.

Products Related to Human BEST1 Protein can be found at Proteins

Additional information

Weight 48 oz
Dimensions 8 × 8 × 8 in

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