Human BAFF Receptor (Recombinant)

Description

Human BAFF Receptor
Catalog number: B2010340
Lot number: Batch Dependent
Expiration Date: Batch dependent
Volume/Weight: 10 ug
pH: 7.4 upon reconstitution
Supplied as: Lyophilized Powder
Appearance: Powder
Applications: highly pure Human BAFF Receptor expressed in E. coli. This protein acts as a TNF Receptor that specifically interacts with BAFF.
Storage: -20C
Keywords: rHuBAFF-R; CD268; TNFRSF13C; BR3
Grade: Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Smulski CR, Eibel H. BAFF and BAFF-Receptor in B Cell Selection and Survival.
Front Immunol. 2018 Oct 8;9:2285.

2: Dörner T, Posch MG, Li Y, Petricoul O, Cabanski M, Milojevic JM, Kamphausen
E, Valentin MA, Simonett C, Mooney L, Hüser A, Gram H, Wagner FD, Oliver SJ.
Treatment of primary Sjögren’s syndrome with ianalumab (VAY736) targeting B
cells by BAFF receptor blockade coupled with enhanced, antibody-dependent
cellular cytotoxicity. Ann Rheum Dis. 2019 May;78(5):641-647.

3: Qin H, Wei G, Sakamaki I, Dong Z, Cheng WA, Smith DL, Wen F, Sun H, Kim K,
Cha S, Bover L, Neelapu SS, Kwak LW. Novel BAFF-Receptor Antibody to Natively
Folded Recombinant Protein Eliminates Drug-Resistant Human B-cell Malignancies
In Vivo. Clin Cancer Res. 2018 Mar 1;24(5):1114-1123.

4: Zheng N, Wang D, Ming H, Zhang H, Yu X. BAFF promotes proliferation of human
mesangial cells through interaction with BAFF-R. BMC Nephrol. 2015 May 15;16:72.

5: Croft M, Siegel RM. Beyond TNF: TNF superfamily cytokines as targets for the
treatment of rheumatic diseases. Nat Rev Rheumatol. 2017 Apr;13(4):217-233.

6: Qin H, Dong Z, Wang X, Cheng WA, Wen F, Xue W, Sun H, Walter M, Wei G, Smith
DL, Sun X, Fei F, Xie J, Panagopoulou TI, Chen CW, Song JY, Aldoss I, Kayembe C,
Sarno L, Müschen M, Inghirami GG, Forman SJ, Kwak LW. CAR T cells targeting
BAFF-R can overcome CD19 antigen loss in B cell malignancies. Sci Transl Med.
2019 Sep 25;11(511):eaaw9414.

7: Shabgah AG, Shariati-Sarabi Z, Tavakkol-Afshari J, Mohammadi M. The role of
BAFF and APRIL in rheumatoid arthritis. J Cell Physiol. 2019
Aug;234(10):17050-17063.

8: Gommerman JL, Rojas OL, Fritz JH. Re-thinking the functions of IgA(+) plasma
cells. Gut Microbes. 2014;5(5):652-62.

9: Dickinson GS, Akkoyunlu M, Bram RJ, Alugupalli KR. BAFF receptor and TACI in
B-1b cell maintenance and antibacterial responses. Ann N Y Acad Sci. 2015
Dec;1362:57-67.

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