Everolimus BSA Conjugate Solution


Catalog #: P2010024 (0.5 mg)
Concentrated solution of Bovine Serum Albumin (BSA) conjugated to Everolimus. A carbon spacer arm of 19.0 Å links BSA to the Everolimus moiety. Each BSA molecule contains several Everolimus units. Dilutions of the provided conjugate can be made in 1X Phosphate Buffer Saline, pH 7.4.

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Everolimus BSA Conjugate

Catalog number: P2010024
Lot number: Batch Dependent
Expiration date: Batch Dependent
Purity: > 95%
Concentration: 1 mg/mL
Package Size: 0.5 mg
Molecular Weight: 71 kDa (average)
Storage: -20°C. Avoid repeated freeze/thaw cycles.
Other names: BSA-Everolimus, Everolimus-BSA, BSA conjugated to Everolimus, 40-O-(2-hydroxyethyl)-sirolimus BSA, Everolimus Bovine Serum Albumin Conjugate, Everolimus [BSA].
Keywords: BSA conjugate, Everolimus, Certican, Zortress, Afinitor, Votubia, Evertor.
Buffer: 1X Phosphate Buffer Saline, pH 7.4.

About Everolimus

Everolimus is a synthetic derivative of the natural compound sirolimus (40-O-(2-hydroxyethyl)-sirolimus). Everolimus has both immunosuppressant and anti-angiogenic properties. As a result, this molecule finds several applications in organ transplant as well as chemotherapy. Inside the cell, Everolimus inhibits the activation of the mammalian target of Rapamycin (sirolimus) (mTOR).

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  • Montero N, Pascual J. Immunosuppression and Post-transplant Hyperglycemia. Curr Diabetes Rev. 2015;11(3):144-54.
  • Everolimus. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-2018 Feb 26.
  • Guan TW, Lin YJ, Ou MY, Chen KB. Efficacy and safety of everolimus treatment on liver transplant recipients: A meta-analysis. Eur J Clin Invest. 2019 Dec;49(12):e13179.
  • Hasskarl J. Everolimus. Recent Results Cancer Res. 2018;211:101-123.
  • Moes DJ, Guchelaar HJ, de Fijter JW. Sirolimus and everolimus in kidney transplantation. Drug Discov Today. 2015 Oct;20(10):1243-9.
  • Vernieri C, Corti F, Nichetti F, Ligorio F, Manglaviti S, Zattarin E, Rea CG, Capri G, Bianchi GV, de Braud F. Everolimus versus alpelisib in advanced hormone receptor-positive HER2-negative breast cancer: targeting different nodes of the PI3K/AKT/mTORC1 pathway with different clinical implications. Breast Cancer Res. 2020 Apr 6;22(1):33.
  • Sammons S, Sedrak MS and Kimmick GG. The Evolving Complexity of Treating Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor-2 (HER2)-Negative Breast Cancer: Special Considerations in Older Breast Cancer Patients-Part I: Early-Stage Disease. Drugs Aging. 2020 Feb 26.

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Additional information

Weight 48 oz
Dimensions 8 × 7 × 6 in

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