Human ALDH2 Protein

Product Description

Human ALDH2 Protein
Catalog number: B2011576
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 100 µg
Molecular Weight or Concentration: 1 mg/mL
Supplied as: Solution
Applications: molecular tool for various biochemical applications
Storage: -20 °C
Keywords: ALDH2 protein, Aldehyde dehydrogenase mitochondrial protein, ALDH E2 protein, mitochondrial Acetaldehyde dehydrogenase 2 protein, ALDH-2, Aldehyde dehydrogenase protein, ALDH 2 protein, ALDH 2 protein, ALDH-2 protein, ALDM protein, MGC1806 protein, ALDH 2, Aldehyde dehy
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Chen CH, Ferreira JCB, Mochly-Rosen D. ALDH2 and Cardiovascular Disease Adv Exp Med Biol. 2019;1193:53-67.
2: Zhao Y, Wang B, Zhang J, He D, Zhang Q, Pan C, Yuan Q, Shi Y, Tang H, Xu F, Wei S, Chen Y. ALDH2 (Aldehyde Dehydrogenase 2) Protects Against Hypoxia-Induced Pulmonary Hypertension Arterioscler Thromb Vasc Biol. 2019 Nov;39(11):2303-2319.
3: Chen CH, Ferreira JC, Gross ER, Mochly-Rosen D. Targeting aldehyde dehydrogenase 2: new therapeutic opportunities Physiol Rev. 2014 Jan;94(1):1-34.
4: Zhong S, Li L, Zhang YL, Zhang L, Lu J, Guo S, Liang N, Ge J, Zhu M, Tao Y, Wu YC, Yin H. Acetaldehyde dehydrogenase 2 interactions with LDLR and AMPK regulate foam cell formation J Clin Invest. 2019 Jan 2;129(1):252-267.
5: Wang S, Wang L, Qin X, Turdi S, Sun D, Culver B, Reiter RJ, Wang X, Zhou H, Ren J. ALDH2 contributes to melatonin-induced protection against APP/PS1 mutation-prompted cardiac anomalies through cGAS-STING-TBK1-mediated regulation of mitophagy Signal Transduct Target Ther. 2020 Jul 24;5(1):119.
6: Yang K, Ren J, Li X, Wang Z, Xue L, Cui S, Sang W, Xu T, Zhang J, Yu J, Liu Z, Shang H, Pang J, Huang X, Chen Y, Xu F. Prevention of aortic dissection and aneurysm via an ALDH2-mediated switch in vascular smooth muscle cell phenotype Eur Heart J. 2020 Jul 7;41(26):2442-2453.
7: Zhang H, Xia Y, Wang F, Luo M, Yang K, Liang S, An S, Wu S, Yang C, Chen D, Xu M, Cai M, To KKW, Fu L. Aldehyde Dehydrogenase 2 Mediates Alcohol-Induced Colorectal Cancer Immune Escape through Stabilizing PD-L1 Expression Adv Sci (Weinh). 2021 Mar 24;8(10):2003404.
8: Jin S, Cao Q, Yang F, Zhu H, Xu S, Chen Q, Wang Z, Lin Y, Cinar R, Pawlosky RJ, Zhang Y, Xiong W, Gao B, Koob GF, Lovinger DM, Zhang L. Brain ethanol metabolism by astrocytic ALDH2 drives the behavioural effects of ethanol intoxication Nat Metab. 2021 Mar;3(3):337-351.
9: Seo W, Gao Y, He Y, Sun J, Xu H, Feng D, Park SH, Cho YE, Guillot A, Ren T, Wu R, Wang J, Kim SJ, Hwang S, Liangpunsakul S, Yang Y, Niu J, Gao B. ALDH2 deficiency promotes alcohol-associated liver cancer by activating oncogenic pathways via oxidized DNA-enriched extracellular vesicles J Hepatol. 2019 Nov;71(5):1000-1011.
10: Xu T, Guo J, Wei M, Wang J, Yang K, Pan C, Pang J, Xue L, Yuan Q, Xue M, Zhang J, Sang W, Jiang T, Chen Y, Xu F. Aldehyde dehydrogenase 2 protects against acute kidney injury by regulating autophagy via the Beclin-1 pathway JCI Insight. 2021 Aug 9;6(15):e138183.

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