Human AADAC Protein

Product Description

Human AADAC Protein
Catalog number: B2011522
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 100 µg
Molecular Weight or Concentration: N/A
Supplied as: Lyophilized
Applications: molecular tool for various biochemical applications
Storage: -20 °C
Keywords: AADAC protein, Arylacetamide deacetylase protein, AADAC protein, Anti-AADAC protein, DAC protein, Esterase protein
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Hirosawa K, Fukami T, Tashiro K, Sakai Y, Kisui F, Nakano M, Nakajima M. Role of Human Arylacetamide Deacetylase (AADAC) on Hydrolysis of Eslicarbazepine Acetate and Effects of AADAC Genetic Polymorphisms on Hydrolase Activity Drug Metab Dispos. 2021 Apr;49(4):322-329.
2: Gabriele M, Puccini P, Lucchi M, Aprile V, Gervasi PG, Longo V. Arylacetamide Deacetylase Enzyme: Presence and Interindividual Variability in Human Lungs Drug Metab Dispos. 2019 Sep;47(9):961-965.
3: Yasuda K, Watanabe K, Fukami T, Nakashima S, Ikushiro SI, Nakajima M, Sakaki T. Epicatechin gallate and epigallocatechin gallate are potent inhibitors of human arylacetamide deacetylase Drug Metab Pharmacokinet. 2021 Aug;39:100397.
4: Honda S, Fukami T, Hirosawa K, Tsujiguchi T, Zhang Y, Nakano M, Uehara S, Uno Y, Yamazaki H, Nakajima M. Differences in Hydrolase Activities in the Liver and Small Intestine between Marmosets and Humans Drug Metab Dispos. 2021 Sep;49(9):718-728.
5: Fukami T, Kariya M, Kurokawa T, Iida A, Nakajima M. Comparison of substrate specificity among human arylacetamide deacetylase and carboxylesterases Eur J Pharm Sci. 2015 Oct 12;78:47-53.
6: Uno Y, Hosokawa M, Imai T. Isolation and characterization of arylacetamide deacetylase in cynomolgus macaques J Vet Med Sci. 2015 Jun;77(6):721-4.
7: Muta K, Fukami T, Nakajima M, Yokoi T. N-Glycosylation during translation is essential for human arylacetamide deacetylase enzyme activity Biochem Pharmacol. 2014 Jan 15;87(2):352-9.
8: Sakai Y, Fukami T, Nagaoka M, Hirosawa K, Ichida H, Sato R, Suzuki K, Nakano M, Nakajima M. Arylacetamide deacetylase as a determinant of the hydrolysis and activation of abiraterone acetate in mice and humans Life Sci. 2021 Nov 1;284:119896.
9: Watanabe A, Fukami T, Nakajima M, Takamiya M, Aoki Y, Yokoi T. Human arylacetamide deacetylase is a principal enzyme in flutamide hydrolysis Drug Metab Dispos. 2009 Jul;37(7):1513-20.
10: Kurokawa T, Fukami T, Yoshida T, Nakajima M. Arylacetamide Deacetylase is Responsible for Activation of Prasugrel in Human and Dog Drug Metab Dispos. 2016 Mar;44(3):409-16.

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