HIV Protease FRET Substrate I

Product Description

HIV Protease FRET Substrate I
Catalog number: B2011376
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 1 mg
Molecular Weight or Concentration: 1532.8 g/mol
Supplied as: Lyophilized
Applications: molecular tool for various biochemical applications
Storage: -20 °C
Keywords: HIV Protease Substrate I
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Beck ZQ, Morris GM, Elder JH. Defining HIV-1 protease substrate selectivity Curr Drug Targets Infect Disord. 2002 Mar;2(1):37-50.
2: Kolli M, Ozen A, Kurt-Yilmaz N, Schiffer CA. HIV-1 protease-substrate coevolution in nelfinavir resistance J Virol. 2014 Jul;88(13):7145-54.
3: Laco GS. HIV-1 protease substrate-groove: Role in substrate recognition and inhibitor resistance Biochimie. 2015 Nov;118:90-103.
4: Rusere LN, Lockbaum GJ, Lee SK, Henes M, Kosovrasti K, Spielvogel E, Nalivaika EA, Swanstrom R, Yilmaz NK, Schiffer CA, Ali A. HIV-1 Protease Inhibitors Incorporating Stereochemically Defined P2′ Ligands To Optimize Hydrogen Bonding in the Substrate Envelope J Med Chem. 2019 Sep 12;62(17):8062-8079.
5: Ahsan M, Pindi C, Senapati S. Electrostatics Plays a Crucial Role in HIV-1 Protease Substrate Binding, Drugs Fail to Take Advantage Biochemistry. 2020 Sep 15;59(36):3316-3331.
6: Deshmukh L, Tugarinov V, Louis JM, Clore GM. Binding kinetics and substrate selectivity in HIV-1 protease-Gag interactions probed at atomic resolution by chemical exchange NMR Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):E9855-E9862.
7: Ozen A, Haliloğlu T, Schiffer CA. Dynamics of preferential substrate recognition in HIV-1 protease: redefining the substrate envelope J Mol Biol. 2011 Jul 22;410(4):726-44.
8: Trylska J, Tozzini V, Chang CE, McCammon JA. HIV-1 protease substrate binding and product release pathways explored with coarse-grained molecular dynamics Biophys J. 2007 Jun 15;92(12):4179-87.
9: Potempa M, Lee SK, Wolfenden R, Swanstrom R. The triple threat of HIV-1 protease inhibitors Curr Top Microbiol Immunol. 2015;389:203-41.
10: Benko Z, Elder RT, Li G, Liang D, Zhao RY. HIV-1 Protease in the Fission Yeast Schizosaccharomyces pombe PLoS One. 2016 Mar 16;11(3):e0151286.

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