Ganglioside GM3 Antibody

Description

Ganglioside GM3 Antibody
Catalog number: B2011036
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 100 ug
Molecular Weight or Concentration: na
Supplied as: Solution
Applications: molecular tool for various chemical, biochemical and immunological applications
Storage: -20°C
Keywords: Anti-GM3 Monoclonal Antibody
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Dorvignit D, Boligan KF, Relova-Hernández E, Clavell M, López A, Labrada M, Simon HU, López-Requena A, Mesa C, von Gunten S. Antitumor effects of the GM3(Neu5Gc) ganglioside-specific humanized antibody 14F7hT against Cmah-transfected cancer cells Sci Rep. 2019 Jul 9;9(1):9921.
2: Bjerregaard-Andersen K, Abraha F, Johannesen H, Oscarson S, Moreno E, Krengel U. Key role of a structural water molecule for the specificity of 14F7-An antitumor antibody targeting the NeuGc GM3 ganglioside Glycobiology. 2021 Dec 18;31(11):1500-1509.
3: Labrada M, Dorvignit D, Hevia G, Rodríguez-Zhurbenko N, Hernández AM, Vázquez AM, Fernández LE. GM3(Neu5Gc) ganglioside: an evolution fixed neoantigen for cancer immunotherapy Semin Oncol. 2018 Jan;45(1-2):41-51.
4: Choi H, Jin UH, Kang SK, Abekura F, Park JY, Kwon KM, Suh SJ, Cho SH, Ha KT, Lee YC, Chung TW, Kim CH. Monosialyl Ganglioside GM3 Decreases Apolipoprotein B-100 Secretion in Liver Cells J Cell Biochem. 2017 Aug;118(8):2168-2181.
5: He D, Fan X, Liu B, Tian Y, Zhang X, Kang L, Tai Y, Liu S, Wang Q, Li Q, Cai J. Generation and characterization of a IgG monoclonal antibody specific for GM3 (NeuGc) ganglioside by immunizing β3Gn-T5 knockout mice Sci Rep. 2018 Feb 7;8(1):2561.
6: Bozic J, Markotic A, Cikes-Culic V, Novak A, Borovac JA, Vucemilovic H, Trgo G, Ticinovic Kurir T. Ganglioside GM3 content in skeletal muscles is increased in type 2 but decreased in type 1 diabetes rat models: Implications of glycosphingolipid metabolism in pathophysiology of diabetes J Diabetes. 2018 Feb;10(2):130-139.
7: Dorvignit D, García-Martínez L, Rossin A, Sosa K, Viera J, Hernández T, Mateo C, Hueber AO, Mesa C, López-Requena A. Antitumor and cytotoxic properties of a humanized antibody specific for the GM3(Neu5Gc) ganglioside Immunobiology. 2015 Dec;220(12):1343-50.
8: Novak A, Režić Mužinić N, Cikeš Čulić V, Božić J, Tičinović Kurir T, Ferhatović L, Puljak L, Markotić A. Renal distribution of ganglioside GM3 in rat models of types 1 and 2 diabetes J Physiol Biochem. 2013 Dec;69(4):727-35.
9: Tsukuda Y, Iwasaki N, Seito N, Kanayama M, Fujitani N, Shinohara Y, Kasahara Y, Onodera T, Suzuki K, Asano T, Minami A, Yamashita T. Ganglioside GM3 has an essential role in the pathogenesis and progression of rheumatoid arthritis PLoS One. 2012;7(6):e40136.
10: Rojas G, Pupo A, Gómez S, Krengel U, Moreno E. Engineering the binding site of an antibody against N-glycolyl GM3: from functional mapping to novel anti-ganglioside specificities ACS Chem Biol. 2013 Feb 15;8(2):376-86.

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