Free Secretory Component from Milk

Product Description

Free Secretory Component from Milk
Catalog number: B2016918
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 50 μg
Molecular Weight or Concentration: 71 kDa
Supplied as: Solution
Applications: a molecular tool for various biochemical applications
Storage: -80°C
Keywords: Secretory component may act as a non-specific microbial scavenger to prevent pathogen interaction with epithelial cells, specifically free secretory component interacts with bacterial antigens toxA of C.difficile and eaeA of E.coli.
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Woodard CS, Splawski JB, Goldblum RM, Denney RM. Characterization of epitopes of human secretory component on free secretory component, secretory IgA, and membrane-associated secretory component J Immunol. 1984 Oct;133(4):2116-25.
2: Murkofsky NA, Lamm ME. Effect of a disulfide-interchange enzyme on the assembly of human secretory immunoglobulin A from immunoglobulin A and free secretory component J Biol Chem. 1979 Dec 10;254(23):12181-4.
3: Tomana M, Zikan J, Kulhavy R, Bennett JC, Mestecky J. Interactions of galactosyltransferase with serum and secretory immunoglobulins and their component chains Mol Immunol. 1993 Feb;30(3):277-86.
4: Jones RM, Schweikart F, Frutiger S, Jaton JC, Hughes GJ. Thiol-disulfide redox buffers maintain a structure of immunoglobulin A that is essential for optimal in vitro binding to secretory component Biochim Biophys Acta. 1998 Dec 8;1429(1):265-74.
5: Demers-Mathieu V, Mathijssen G, Dapra C, Do DM, Medo E. Active free secretory component and secretory IgA in human milk: do maternal vaccination, allergy, infection, mode of delivery, nutrition and active lifestyle change their concentrations? Pediatr Res. 2021 Mar;89(4):795-802.
6: de Araújo AN, Giugliano LG. Lactoferrin and free secretory component of human milk inhibit the adhesion of enteropathogenic Escherichia coli to HeLa cells BMC Microbiol. 2001;1:25.
7: Purkayastha S, Rao CV, Lamm ME. Structure of the carbohydrate chain of free secretory component from human milk J Biol Chem. 1979 Jul 25;254(14):6583-7.
8: Giugliano LG, Ribeiro ST, Vainstein MH, Ulhoa CJ. Free secretory component and lactoferrin of human milk inhibit the adhesion of enterotoxigenic Escherichia coli J Med Microbiol. 1995 Jan;42(1):3-9.
9: Hughes GJ, Frutiger S, Savoy LA, Reason AJ, Morris HR, Jaton JC. Human free secretory component is composed of the first 585 amino acid residues of the polymeric immunoglobulin receptor FEBS Lett. 1997 Jun 30;410(2-3):443-6.
10: Gore ME, Bunnage HJ, McIlhinney RA. A monoclonal antibody which differentiates between bound and free human secretory component Eur J Immunol. 1984 Apr;14(4):344-9.

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