Eosinophil-derived Neurotoxin (Native Human)

Product Description

Eosinophil-derived Neurotoxin (Native Human)
Catalog number: B2016909
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 50 μg
Molecular Weight or Concentration: 18 kDa
Supplied as: Solution
Applications: a molecular tool for various biochemical applications
Storage: -80°C
Keywords: Non-secretory ribonuclease, Eosinophil-derived neurotoxin, RNase UpI-2, Ribonuclease 2 (RNase 2), Ribonuclease US
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Newton DL, Nicholls PJ, Rybak SM, Youle RJ. Expression and characterization of recombinant human eosinophil-derived neurotoxin and eosinophil-derived neurotoxin-anti-transferrin receptor sFv J Biol Chem. 1994 Oct 28;269(43):26739-45.
2: Sun L, Li MS, Fisher LM, Spry CJ. Expression in Escherichia coli and purification of human eosinophil-derived neurotoxin with ribonuclease activity Protein Expr Purif. 1995 Oct;6(5):685-92.
3: Leonidas DD, Boix E, Prill R, Suzuki M, Turton R, Minson K, Swaminathan GJ, Youle RJ, Acharya KR. Mapping the ribonucleolytic active site of eosinophil-derived neurotoxin (EDN). High resolution crystal structures of EDN complexes with adenylic nucleotide inhibitors J Biol Chem. 2001 May 4;276(18):15009-17.
4: Liang S, Acharya KR. Structural basis of substrate specificity in porcine RNase 4 FEBS J. 2016 Mar;283(5):912-28.
5: Newton DL, Walbridge S, Mikulski SM, Ardelt W, Shogen K, Ackerman SJ, Rybak SM, Youle RJ. Toxicity of an antitumor ribonuclease to Purkinje neurons J Neurosci. 1994 Feb;14(2):538-44.
6: Ackerman SJ, Gleich GJ, Loegering DA, Richardson BA, Butterworth AE. Comparative toxicity of purified human eosinophil granule cationic proteins for schistosomula of Schistosoma mansoni Am J Trop Med Hyg. 1985 Jul;34(4):735-45.
7: Domachowske JB, Dyer KD, Adams AG, Leto TL, Rosenberg HF. Eosinophil cationic protein/RNase 3 is another RNase A-family ribonuclease with direct antiviral activity Nucleic Acids Res. 1998 Jul 15;26(14):3358-63.
8: Furuta GT, Nieuwenhuis EE, Karhausen J, Gleich G, Blumberg RS, Lee JJ, Ackerman SJ. Eosinophils alter colonic epithelial barrier function: role for major basic protein Am J Physiol Gastrointest Liver Physiol. 2005 Nov;289(5):G890-7.
9: Moy JN, Thomas LL, Whisler LC. Eosinophil major basic protein enhances the expression of neutrophil CR3 and p150,95 J Allergy Clin Immunol. 1993 Oct;92(4):598-606.
10: Motojima S, Frigas E, Loegering DA, Gleich GJ. Toxicity of eosinophil cationic proteins for guinea pig tracheal epithelium in vitro Am Rev Respir Dis. 1989 Mar;139(3):801-5.

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