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EMAP-II (Human, Recombinant)

$695.00 $495.00

Catalog Number: B2010351 (10 ug)
EMAP-II (Human, Recombinant) is a high quality research product used as highly pure EMAP-II (Human, Recombinant) expressed in HEK 293. This protein acts as a proinflammatory cytokine and chemoattractant of macrophages. Custom bulk orders of this product are available upon request.

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SKU: B2010351 Categories: , ,

Description

EMAP-II (Human, Recombinant)
Catalog number: B2010351
Lot number: Batch Dependent
Expiration Date: Batch dependent
Volume/Weight: 10 ug
pH: 7.4 upon reconstitution
Supplied as: Lyophilized Powder
Appearance: Powder
Applications: highly pure EMAP-II (Human, Recombinant) expressed in HEK 293. This protein acts as a proinflammatory cytokine and chemoattractant of macrophages.
Storage: -20C
Keywords: rHuEMAP-II; Endothelial-Monocyte A Activating Polypeptide II; EMAP-2; AIMP1
Grade: Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Yu Q, Liu L, Wang P, Yao Y, Xue Y, Liu Y. EMAP-II sensitize U87MG and glioma
stem-like cells to temozolomide via induction of autophagy-mediated cell death
and G2/M arrest. Cell Cycle. 2017 Jun 3;16(11):1085-1092.
PMC5499844.

2: Kolomiiets LA, Vorobyova NV, Lozhko DM, Zayets VM, Kornelyuk AI.
Stabilization of AIMP1/p43 and EMAP II recombinant proteins in the complexes
with polysaccharide dextran-70. Pharmacol Rep. 2020 Feb;72(1):238-245.

3: Nührenberg TG, Langwieser N, Schwarz JB, Hou Y, Frank P, Sorge F, Matschurat
S, Seidl S, Kastrati A, Schömig A, Clauss MA, Zohlnhöfer D. EMAP-II
downregulation contributes to the beneficial effects of rapamycin after vascular
injury. Cardiovasc Res. 2008 Feb 1;77(3):580-9.

4: Youssef MM, Symonds P, Ellis IO, Murray JC. EMAP-II-dependent lymphocyte
killing is associated with hypoxia in colorectal cancer. Br J Cancer. 2006 Sep
18;95(6):735-43.

5: Kayton ML, Libutti SK. Endothelial monocyte activating polypeptide II (EMAP
II) enhances the effect of TNF on tumor-associated vasculature. Curr Opin
Investig Drugs. 2001 Jan;2(1):136-8. P

6: Chen L, Xue Y, Zheng J, Liu X, Liu J, Chen J, Li Z, Xi Z, Teng H, Wang P, Liu
L, Liu Y. MiR-429 Regulated by Endothelial Monocyte Activating Polypeptide-II
(EMAP-II) Influences Blood-Tumor Barrier Permeability by Inhibiting the
Expressions of ZO-1, Occludin and Claudin-5. Front Mol Neurosci. 2018 Feb
7;11:35.

7: Lal CV, Schwarz MA. Vascular mediators in chronic lung disease of infancy:
role of endothelial monocyte activating polypeptide II (EMAP II). Birth Defects
Res A Clin Mol Teratol. 2014 Mar;100(3):180-8.

8: Yuan C, Yan L, Solanki P, Vatner SF, Vatner DE, Schwarz MA. Blockade of EMAP
II protects cardiac function after chronic myocardial infarction by inducing
angiogenesis. J Mol Cell Cardiol. 2015 Feb;79:224-31.
9: Matschurat S, Knies UE, Person V, Fink L, Stoelcker B, Ebenebe C, Behrensdorf
HA, Schaper J, Clauss M. Regulation of EMAP II by hypoxia. Am J Pathol. 2003
Jan;162(1):93-103.

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