Autotaxin Human Recombinant

Product Description

Autotaxin Human Recombinant
Catalog number: B2016926
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 50 µg
Molecular Weight or Concentration: 96.2 kDa
Supplied as: Solution
Applications: a molecular tool for various biochemical applications
Storage: -80°C
Keywords: ATX, EC 3.1.1.39, Ectonucleotide Pyrophosphatase/Phosphodiesterase-2, ENPP-2, Lyso-PLD, Lysophospholipase D
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Song Y, Dilger E, Bell J, Barton WA, Fang X. Large scale purification and characterization of recombinant human autotaxin/lysophospholipase D from mammalian cells BMB Rep. 2010 Aug;43(8):541-6.
2: Nakamura K, Igarashi K, Ide K, Ohkawa R, Okubo S, Yokota H, Masuda A, Oshima N, Takeuchi T, Nangaku M, Okudaira S, Arai H, Ikeda H, Aoki J, Yatomi Y. Validation of an autotaxin enzyme immunoassay in human serum samples and its application to hypoalbuminemia differentiation Clin Chim Acta. 2008 Feb;388(1-2):51-8.
3: Gaetano CG, Samadi N, Tomsig JL, Macdonald TL, Lynch KR, Brindley DN. Inhibition of autotaxin production or activity blocks lysophosphatidylcholine-induced migration of human breast cancer and melanoma cells Mol Carcinog. 2009 Sep;48(9):801-9.
4: Bolier R, Tolenaars D, Kremer AE, Saris J, Parés A, Verheij J, Bosma PJ, Beuers U, Oude Elferink RPJ. Enteroendocrine cells are a potential source of serum autotaxin in men Biochim Biophys Acta. 2016 Apr;1862(4):696-704.
5: Zhao Y, Hasse S, Vaillancourt M, Zhao C, Davis L, Boilard E, Fortin P, Di Battista J, Poubelle PE, Bourgoin SG. Phospholipase A1 Member A Activates Fibroblast-like Synoviocytes through the Autotaxin-Lysophosphatidic Acid Receptor Axis Int J Mol Sci. 2021 Nov 24;22(23):12685.
6: Wu JM, Xu Y, Skill NJ, Sheng H, Zhao Z, Yu M, Saxena R, Maluccio MA. Autotaxin expression and its connection with the TNF-alpha-NF-kappaB axis in human hepatocellular carcinoma Mol Cancer. 2010 Mar 31;9:71.
7: Haga A, Hashimoto K, Tanaka N, Nakamura KT, Deyashiki Y. Scalable purification and characterization of the extracellular domain of human autotaxin from prokaryotic cells Protein Expr Purif. 2008 May;59(1):9-17.
8: Kawagoe H, Stracke ML, Nakamura H, Sano K. Expression and transcriptional regulation of the PD-Ialpha/autotaxin gene in neuroblastoma Cancer Res. 1997 Jun 15;57(12):2516-21.
9: Sato K, Malchinkhuu E, Muraki T, Ishikawa K, Hayashi K, Tosaka M, Mochiduki A, Inoue K, Tomura H, Mogi C, Nochi H, Tamoto K, Okajima F. Identification of autotaxin as a neurite retraction-inducing factor of PC12 cells in cerebrospinal fluid and its possible sources J Neurochem. 2005 Feb;92(4):904-14.
10: David M, Wannecq E, Descotes F, Jansen S, Deux B, Ribeiro J, Serre CM, Grès S, Bendriss-Vermare N, Bollen M, Saez S, Aoki J, Saulnier-Blache JS, Clézardin P, Peyruchaud O. Cancer cell expression of autotaxin controls bone metastasis formation in mouse through lysophosphatidic acid-dependent activation of osteoclasts PLoS One. 2010 Mar 17;5(3):e9741.

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