α-Defensin-4 (Human)

Product Description

α-Defensin-4 (Human)
Catalog number: MDP0792
CAS Number: 185461-45-4
Sequence: Val-Cys-Ser-Cys-Arg-Leu-Val-Phe-Cys-Arg-Arg-Thr-Glu-Leu-Arg-Val-Gly-Asn-Cys-Leu-Ile-Gly-Gly-Val-Ser-Phe-Thr-Tyr-Cys-Cys-Thr-Arg-Val (Disulfide bonds between Cys2-Cys30, Cys4-Cys19, and Cys9-Cys29)
Amount: 100 ug
Molecular Weight: 3709.2 g/mol
Supplied as: Powder
Applications: molecular tool for various biochemical applications
Storage: -20 °C
WARNING: For in vitro Research Use Only. NOT for use on humans or animals.
Grade: Biotechnology grade. All products are highly pure.

References:
1: Etienne G, Dupouy M, Costaglioli P, Chollet C, Lagarde V, Pasquet JM, Reiffers J, Garbay B, Mahon FX, Turcq B. α-defensin 1-3 and α-defensin 4 as predictive markers of imatinib resistance and relapse in CML patients Dis Markers. 2011;30(5):221-7.
2: Ehmann D, Koeninger L, Wendler J, Malek NP, Stange EF, Wehkamp J, Jensen BAH. Fragmentation of Human Neutrophil α-Defensin 4 to Combat Multidrug Resistant Bacteria Front Microbiol. 2020 Jun 3;11:1147.
3: Tai KP, Le VV, Selsted ME, Ouellette AJ. Hydrophobic determinants of α-defensin bactericidal activity Infect Immun. 2014 Jun;82(6):2195-202.
4: Kamdar K, Maemoto A, Qu X, Young SK, Ouellette AJ. In vitro activation of the rhesus macaque myeloid alpha-defensin precursor proRMAD-4 by neutrophil serine proteinases J Biol Chem. 2008 Nov 21;283(47):32361-8.
5: Wu Z, Cocchi F, Gentles D, Ericksen B, Lubkowski J, Devico A, Lehrer RI, Lu W. Human neutrophil alpha-defensin 4 inhibits HIV-1 infection in vitro FEBS Lett. 2005 Jan 3;579(1):162-6.
6: Atkins JL, Hammamieh R, Jett M, Gorbunov NV, Asher LV, Kiang JG. Alpha-defensin-like product and asymmetric dimethylarginine increase in mesenteric lymph after hemorrhage in anesthetized rat Shock. 2008 Oct;30(4):411-6.
7: Agadi N, Maity A, Jha AK, Chakrabarti R, Kumar A. Distinct mode of membrane interaction and disintegration by diverse class of antimicrobial peptides Biochim Biophys Acta Biomembr. 2022 Dec 1;1864(12):184047.
8: Kamekura R, Imai R, Takano K, Yamashita K, Jitsukawa S, Nagaya T, Ito F, Hirao M, Tsubota H, Himi T. Expression and Localization of Human Defensins in Palatine Tonsils Adv Otorhinolaryngol. 2016;77:112-8.
9: Llenado RA, Weeks CS, Cocco MJ, Ouellette AJ. Electropositive charge in alpha-defensin bactericidal activity: functional effects of Lys-for-Arg substitutions vary with the peptide primary structure Infect Immun. 2009 Nov;77(11):5035-43.
10: Jourdain ML, Pierrard L, Kanagaratnam L, Velard F, Sergheraert J, Lefèvre B, Gangloff SC, Braux J. Antimicrobial peptide gene expression in periodontitis patients: A pilot study J Clin Periodontol. 2018 May;45(5):524-537.

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