α-Defensin-2 (Human)

Product Description

α-Defensin-2 (Human)
Catalog number: MDP0789
CAS Number: 1401381-87-0
Sequence: Cys-Tyr-Cys-Arg-Ile-Pro-Ala-Cys-Ile-Ala-Gly-Glu-Arg-Arg-Tyr-Gly-Thr-Cys-Ile-Tyr-Gln-Gly-Arg-Leu-Trp-Ala-Phe-Cys-Cys (Disulfide bonds between Cys1-Cys29, Cys3-Cys18, and Cys8-Cys28)
Amount: 100 ug
Molecular Weight: 3370.8 g/mol
Supplied as: Powder
Applications: molecular tool for various biochemical applications
Storage: -20 °C
WARNING: For in vitro Research Use Only. NOT for use on humans or animals.
Grade: Biotechnology grade. All products are highly pure.

References:
1: Gökçınar NB, Karabulut AA, Onaran Z, Yumuşak E, Budak Yıldıran FA. Elevated Tear Human Neutrophil Peptides 1-3, Human Beta Defensin-2 Levels and Conjunctival Cathelicidin LL-37 Gene Expression in Ocular Rosacea Ocul Immunol Inflamm. 2019;27(7):1174-1183.
2: Goebel C, Mackay LG, Vickers ER, Mather LE. Determination of defensin HNP-1, HNP-2, and HNP-3 in human saliva by using LC/MS Peptides. 2000 Jun;21(6):757-65.
3: Gácser A, Tiszlavicz Z, Németh T, Seprényi G, Mándi Y. Induction of human defensins by intestinal Caco-2 cells after interactions with opportunistic Candida species Microbes Infect. 2014 Jan;16(1):80-5.
4: Selsted ME, Harwig SS. Determination of the disulfide array in the human defensin HNP-2. A covalently cyclized peptide J Biol Chem. 1989 Mar 5;264(7):4003-7.
5: Zhang L, Yu W, He T, Yu J, Caffrey RE, Dalmasso EA, Fu S, Pham T, Mei J, Ho JJ, Zhang W, Lopez P, Ho DD. Contribution of human alpha-defensin 1, 2, and 3 to the anti-HIV-1 activity of CD8 antiviral factor Science. 2002 Nov 1;298(5595):995-1000.
6: van den Broek I, Sparidans RW, Schellens JH, Beijnen JH. Validation of a quantitative assay for human neutrophil peptide-1, -2, and -3 in human plasma and serum by liquid chromatography coupled to tandem mass spectrometry J Chromatogr B Analyt Technol Biomed Life Sci. 2010 May 1;878(15-16):1085-92.
7: Das S, Vince GS, Lewis-Jones I, Bates MD, Gazvani R. The expression of human alpha and beta defensin in the endometrium and their effect on implantation J Assist Reprod Genet. 2007 Nov;24(11):533-9.
8: Chertov O, Michiel DF, Xu L, Wang JM, Tani K, Murphy WJ, Longo DL, Taub DD, Oppenheim JJ. Identification of defensin-1, defensin-2, and CAP37/azurocidin as T-cell chemoattractant proteins released from interleukin-8-stimulated neutrophils J Biol Chem. 1996 Feb 9;271(6):2935-40.
9: Lundy FT, Orr DF, Gallagher JR, Maxwell P, Shaw C, Napier SS, Gerald Cowan C, Lamey PJ, Marley JJ. Identification and overexpression of human neutrophil alpha-defensins (human neutrophil peptides 1, 2 and 3) in squamous cell carcinomas of the human tongue Oral Oncol. 2004 Feb;40(2):139-44.
10: Xie C, Zeng P, Ericksen B, Wu Z, Lu WY, Lu W. Effects of the terminal charges in human neutrophil alpha-defensin 2 on its bactericidal and membrane activity Peptides. 2005 Dec;26(12):2377-83.

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