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4-Nitrophenyl Phenylphosphonate (Highly Pure)

Original price was: $795.00.Current price is: $395.00.

Catalog Number: B2012604 (100 mg)
4-Nitrophenyl Phenylphosphonate (Highly Pure) is a high quality substrate for 5’-nucleotide phosphodiesterases and preferred because of its stability, ease of synthesis, and higher rate of hydrolysis under saturating conditions. This product has been used as molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

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Product Description

4-Nitrophenyl Phenylphosphonate (Highly Pure)
Catalog number: B2012604
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 100 mg
Molecular Weight or Concentration: 279.2 g/mol
Supplied as: Lyophilized Powder
Applications: molecular tool for various biochemical applications
Storage: -20°C
Keywords: bis(4-Nitrophenyl) Phenylphosphonate, p-Nitrophenyl Phenylphosphonate, para-Nitrophenyl Phenylphosphonate, NPPP
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Liao TH, Hsieh JC. Hydrolysis of p-nitrophenyl phenylphosphonate catalysed by bovine pancreatic deoxyribonuclease Biochem J. 1988 Nov 1;255(3):781-7.
2: Forsyth CS, Chambers JE. Activation and degradation of the phosphorothionate insecticides parathion and EPN by rat brain Biochem Pharmacol. 1989 May 15;38(10):1597-603.
3: Abou-Donia MB, Hu ZH, Lapadula DM, Gupta RP. Mechanisms of joint neurotoxicity of n-hexane, methyl isobutyl ketone and O-ethyl O-4-nitrophenyl phenylphosphonothioate in hens J Pharmacol Exp Ther. 1991 Apr;257(1):282-9.
4: Tawfik DS, Green BS, Eshhar Z. Detection of catalytic monoclonal antibodies Anal Biochem. 1992 Apr;202(1):35-9.
5: Pla A, Johnson MK. Degradation by rat tissues in vitro of organophosphorus esters which inhibit cholinesterase Biochem Pharmacol. 1989 May 1;38(9):1527-33.
6: Terrier F, Rodriguez-Dafonte P, Le Guével E, Moutiers G. Revisiting the reactivity of oximate alpha-nucleophiles with electrophilic phosphorus centers. Relevance to detoxification of sarin, soman and DFP under mild conditions Org Biomol Chem. 2006 Dec 7;4(23):4352-63.
7: Deussen HJ, Danielsen S, Breinholt J, Borchert TV. A novel biotinylated suicide inhibitor for directed molecular evolution of lipolytic enzymes Bioorg Med Chem. 2000 Mar;8(3):507-13.
8: Somwang P, Yanola J, Suwan W, Walton C, Lumjuan N, Prapanthadara LA, Somboon P. Enzymes-based resistant mechanism in pyrethroid resistant and susceptible Aedes aegypti strains from northern Thailand Parasitol Res. 2011 Sep;109(3):531-7.
9: Wang CQ, Haxhinasto S, Garcet S, Kunjravia N, Cueto I, Gonzalez J, Rambhia D, Harari O, Sleeman MA, Hamilton JD, Lim WK, Freudenberg J, Kalliolias GD, Thakker P, Bissonnette R, Krueger JG. Comparison of the Inflammatory Circuits in Psoriasis Vulgaris, Non‒Pustular Palmoplantar Psoriasis, and Palmoplantar Pustular Psoriasis J Invest Dermatol. 2023 Jan;143(1):87-97.e14.
10: Kobayashi Y, Fukami T, Higuchi R, Nakajima M, Yokoi T. Metabolic activation by human arylacetamide deacetylase, CYP2E1, and CYP1A2 causes phenacetin-induced methemoglobinemia Biochem Pharmacol. 2012 Nov 1;84(9):1196-206.

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Additional Information

Weight 48 oz
Dimensions 8 × 8 × 8 in

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