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SARS-CoV-2 Spike RBD (Wild type)

$895.00

Catalog Number: B2010505 (100 ug)
SARS-CoV-2 Spike RBD (Wild type) is a highly pure recombinant SARS-CoV-2 RBD from the origical wild type lineage expressed in insect cells. This product has been used as molecular component of many serological and antigenic assays for SARS-CoV-2. It has also been used in a wide array of other biochemical and immunological applications. Custom bulk amounts of this product are available upon request.

Live enquiry about this product via Text/SMS: 1-858-900-3210.

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SKU: B2010505 Categories: ,

Description

SARS-CoV-2 Spike RBD (Wild type)
Catalog number: B2010505
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 100 ug
Molecular Weight or Concentration: 27 kDa
Supplied as: Lyophilized Powder
Applications: molecular component of many serological and antigenic assays for SARS-CoV-2
Storage: -20℃
Keywords: Spike RBD, S1 RBD, Wild Type RBD
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
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Wang X. Structure of the SARS-CoV-2 spike receptor-binding domain bound to the
ACE2 receptor. Nature. 2020 May;581(7807):215-220.

2: Weisblum Y, Schmidt F, Zhang F, DaSilva J, Poston D, Lorenzi JC, Muecksch F,
Rutkowska M, Hoffmann HH, Michailidis E, Gaebler C, Agudelo M, Cho A, Wang Z,
Gazumyan A, Cipolla M, Luchsinger L, Hillyer CD, Caskey M, Robbiani DF, Rice CM,
Nussenzweig MC, Hatziioannou T, Bieniasz PD. Escape from neutralizing antibodies
by SARS-CoV-2 spike protein variants. Elife. 2020 Oct 28;9:e61312.

3: Barnes CO, Jette CA, Abernathy ME, Dam KA, Esswein SR, Gristick HB, Malyutin
AG, Sharaf NG, Huey-Tubman KE, Lee YE, Robbiani DF, Nussenzweig MC, West AP Jr,
Bjorkman PJ. SARS-CoV-2 neutralizing antibody structures inform therapeutic
strategies. Nature. 2020 Dec;588(7839):682-687.

4: Wang Q, Zhang Y, Wu L, Niu S, Song C, Zhang Z, Lu G, Qiao C, Hu Y, Yuen KY,
Wang Q, Zhou H, Yan J, Qi J. Structural and Functional Basis of SARS-CoV-2 Entry
by Using Human ACE2. Cell. 2020 May 14;181(4):894-904.e9.

5: Pillay TS. Gene of the month: the 2019-nCoV/SARS-CoV-2 novel coronavirus
spike protein. J Clin Pathol. 2020 Jul;73(7):366-369.

6: Weissman D, Alameh MG, de Silva T, Collini P, Hornsby H, Brown R, LaBranche
CC, Edwards RJ, Sutherland L, Santra S, Mansouri K, Gobeil S, McDanal C, Pardi
N, Hengartner N, Lin PJC, Tam Y, Shaw PA, Lewis MG, Boesler C, Şahin U, Acharya
P, Haynes BF, Korber B, Montefiori DC. D614G Spike Mutation Increases SARS CoV-2
Susceptibility to Neutralization. Cell Host Microbe. 2021 Jan 13;29(1):23-31.e4.

7: Greaney AJ, Starr TN, Gilchuk P, Zost SJ, Binshtein E, Loes AN, Hilton SK,
Huddleston J, Eguia R, Crawford KHD, Dingens AS, Nargi RS, Sutton RE,
Suryadevara N, Rothlauf PW, Liu Z, Whelan SPJ, Carnahan RH, Crowe JE Jr, Bloom
JD. Complete Mapping of Mutations to the SARS-CoV-2 Spike Receptor-Binding
Domain that Escape Antibody Recognition. Cell Host Microbe. 2021 Jan
13;29(1):44-57.e9.

8: Buzhdygan TP, DeOre BJ, Baldwin-Leclair A, Bullock TA, McGary HM, Khan JA,
Razmpour R, Hale JF, Galie PA, Potula R, Andrews AM, Ramirez SH. The SARS-CoV-2
spike protein alters barrier function in 2D static and 3D microfluidic in-vitro
models of the human blood-brain barrier. Neurobiol Dis. 2020 Dec;146:105131.

9: Othman H, Bouslama Z, Brandenburg JT, da Rocha J, Hamdi Y, Ghedira K, Srairi-
Abid N, Hazelhurst S. Interaction of the spike protein RBD from SARS-CoV-2 with
ACE2: Similarity with SARS-CoV, hot-spot analysis and effect of the receptor
polymorphism. Biochem Biophys Res Commun. 2020 Jun 30;527(3):702-708.
10: Cao L, Goreshnik I, Coventry B, Case JB, Miller L, Kozodoy L, Chen RE,
Carter L, Walls AC, Park YJ, Strauch EM, Stewart L, Diamond MS, Veesler D, Baker
D. De novo design of picomolar SARS-CoV-2 miniprotein inhibitors. Science. 2020
Oct 23;370(6515):426-431.

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