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Recombinant HCV NS3/4A Protease

$695.00

Catalog Number: B2011289 (5 µg)
Recombinant HCV NS3/4A Protease is a high quality recombinant HCV NS3/4A protease (genotype 1b) expressed in E. Coli with NS4A co-factor fused to the N-terminus of NS3 protease domain. This product has been used as molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

Live enquiry about this product via Text/SMS: 1-858-900-3210.

In stock

SKU: B2011289 Categories: ,

Description

Recombinant HCV NS3/4A Protease
Catalog number: B2011289
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 5 µg
Molecular Weight or Concentration: 22.7 kDa
Supplied as: Solution
Applications: molecular tool for various biochemical applications
Storage: -80 °C
Keywords: HCV NS3/4A protease genotype 1b, recombinant
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Hu K, Zhu Z, Mathahs MM, Tran H, Bommer J, Testa CA, Schmidt WN. Metalloprotoporphyrin Inhibition of HCV NS3-4A Protease: Structure-Activity Relationships Drug Des Devel Ther. 2020 Feb 24;14:757-771.
2: Tsantrizos YS. TMC-435, an NS3/4A protease inhibitor for the treatment of HCV infection Curr Opin Investig Drugs. 2009 Aug;10(8):871-81.
3: Telaprevir Drugs R D. 2010;10(3):179-202.
4: Fatima K, Tahir M, Qadri I. Development of robust in vitro serine protease assay based on recombinant Pakistani HCV NS3-4A protease Virus Res. 2011 Sep;160(1-2):230-7.
5: Naggie S, Patel K, McHutchison J. Hepatitis C virus directly acting antivirals: current developments with NS3/4A HCV serine protease inhibitors J Antimicrob Chemother. 2010 Oct;65(10):2063-9.
6: Boceprevir Drugs R D. 2010;10(3):203-10.
7: Gottwein JM, Scheel TK, Jensen TB, Ghanem L, Bukh J. Differential efficacy of protease inhibitors against HCV genotypes 2a, 3a, 5a, and 6a NS3/4A protease recombinant viruses Gastroenterology. 2011 Sep;141(3):1067-79.
8: Breiman A, Vitour D, Vilasco M, Ottone C, Molina S, Pichard L, Fournier C, Delgrange D, Charneau P, Duverlie G, Wychowski C, Maurel P, Meurs EF. A hepatitis C virus (HCV) NS3/4A protease-dependent strategy for the identification and purification of HCV-infected cells J Gen Virol. 2006 Dec;87(Pt 12):3587-3598.
9: Liapakis AM, Jacobson I. Telaprevir user’s guide Liver Int. 2012 Feb;32 Suppl 1:17-25.
10: Avolio S, Summa V. Advances in the development of macrocyclic inhibitors of hepatitis C virus NS3-4A protease Curr Top Med Chem. 2010;10(14):1403-22.

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