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Phosphoinositide-3-kinase (PI3 kinase, Human)

$1,050.00

Catalog Number: B2010514 (20 ug)
Phosphoinositide-3-kinase (PI3 kinase, Human) is a highly pure complex of full-length human p110 and recombinant full length, human p85α. This product has been used as molecular tool for the study of enzyme kinetics. It has also been used in a wide array of other biochemical and immunological applications. Custom bulk amounts of this product are available upon request.

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Description

Phosphoinositide-3-kinase (PI3 kinase, Human)
Catalog number: B2010514
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 20 ug
Molecular Weight or Concentration: 129/88 kDa
Supplied as: Solution
Applications: molecular tool for the study of enzyme kinetics
Storage: −20°C
Keywords: Phosphoinositide-3-kinase, catalytic, alpha, PIK3CA, PtdIns-3-kinase p110
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Choi S, Houdek X, Anderson RA. Phosphoinositide 3-kinase pathways and
autophagy require phosphatidylinositol phosphate kinases. Adv Biol Regul. 2018
May;68:31-38. .

2: Ramazzotti G, Ratti S, Fiume R, Follo MY, Billi AM, Rusciano I, Owusu Obeng
E, Manzoli L, Cocco L, Faenza I. Phosphoinositide 3 Kinase Signaling in Human
Stem Cells from Reprogramming to Differentiation: A Tale in Cytoplasmic and
Nuclear Compartments. Int J Mol Sci. 2019 Apr 24;20(8):2026.

3: Bi Y, Zhang Y, Ren J. Phosphoinositide 3-kinase therapy in diabetic
cardiomyopathy: unravelling an enigma. Am J Physiol Heart Circ Physiol. 2020 May
1;318(5):H1029-H1031.

4: Chin CK, Nastoupil LJ. Novel Agents Beyond Immunomodulatory Agents and
Phosphoinositide-3-Kinase for Follicular Lymphoma. Hematol Oncol Clin North Am.
2020 Aug;34(4):743-756.

5: Maffucci T, Falasca M. Inositol Polyphosphate-Based Compounds as Inhibitors
of Phosphoinositide 3-Kinase-Dependent Signaling. Int J Mol Sci. 2020 Sep
29;21(19):7198.

6: Condliffe AM, Chandra A. Respiratory Manifestations of the Activated
Phosphoinositide 3-Kinase Delta Syndrome. Front Immunol. 2018 Mar 5;9:338.

7: Mazloumi Gavgani F, Smith Arnesen V, Jacobsen RG, Krakstad C, Hoivik EA,
Lewis AE. Class I Phosphoinositide 3-Kinase PIK3CA/p110α and
PIK3CB/p110β Isoforms in Endometrial Cancer. Int J Mol Sci. 2018 Dec
7;19(12):3931.

8: Tang LA, Dixon BN, Maples KT, Poppiti KM, Peterson TJ. Current and
Investigational Agents Targeting the Phosphoinositide 3-Kinase Pathway.
Pharmacotherapy. 2018 Oct;38(10):1058-1067.

9: Qiu X, Tian Y, Liang Z, Sun Y, Li Z, Bian J. Recent discovery of
phosphoinositide 3-kinase γ inhibitors for the treatment of immune diseases and
cancers. Future Med Chem. 2019 Aug;11(16):2151-2169.
10: Hurley JH, Young LN. Mechanisms of Autophagy Initiation. Annu Rev Biochem.
2017 Jun 20;86:225-244.

Products Related to Phosphoinositide-3-kinase (PI3 kinase, Human) : Enzymes

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