N-Succinimidyl 4-Maleimidobutyrate


Catalog Number: B2012280 (50 mg)
N-Succinimidyl 4-Maleimidobutyrate is a high quality Cross-linking Reagent. This product has been used as molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

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N-Succinimidyl 4-Maleimidobutyrate
Catalog number: B2012280
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 50 mg
Molecular Weight or Concentration: 280.3 g/mol
Supplied as: Powder
Applications: molecular tool for various biochemical applications
Storage: -20C
Keywords: GMBS, 4-Maleimidobutyric Acid N-Succinimidyl Ester
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

1: Nymann Petersen I, Madsen J, Bernard Matthijs Poulie C, Kjær A, Manfred Herth M. One-Step Synthesis of N-Succinimidyl-4-[(18)F]Fluorobenzoate ([(18)F]SFB) Molecules. 2019 Sep 22;24(19):3436.
2: Coort SL, Willems J, Coumans WA, van der Vusse GJ, Bonen A, Glatz JF, Luiken JJ. Sulfo-N-succinimidyl esters of long chain fatty acids specifically inhibit fatty acid translocase (FAT/CD36)-mediated cellular fatty acid uptake Mol Cell Biochem. 2002 Oct;239(1-2):213-9.
3: Li W, Lang L, Niu G, Guo N, Ma Y, Kiesewetter DO, Shen B, Chen X. N-Succinimidyl 4-[(18)F]-fluoromethylbenzoate-labeled dimeric RGD peptide for imaging tumor integrin expression Amino Acids. 2012 Sep;43(3):1349-57.
4: Vaidyanathan G, McDougald D, Choi J, Pruszynski M, Koumarianou E, Zhou Z, Zalutsky MR. N-Succinimidyl 3-((4-(4-[(18)F]fluorobutyl)-1H-1,2,3-triazol-1-yl)methyl)-5-(guanidinomethyl)benzoate ([(18)F]SFBTMGMB): a residualizing label for (18)F-labeling of internalizing biomolecules Org Biomol Chem. 2016 Jan 28;14(4):1261-71.
5: Zhou Z, McDougald D, Meshaw R, Balyasnikova I, Zalutsky MR, Vaidyanathan G. Labeling single domain antibody fragments with (18)F using a novel residualizing prosthetic agent – N-succinimidyl 3-(1-(2-(2-(2-(2-[(18)F]fluoroethoxy)ethoxy)ethoxy)ethyl)-1H-1,2,3-triazol-4-yl)-5-(guanidinomethyl)benzoate Nucl Med Biol. 2021 Sep-Oct;100-101:24-35.
6: Choi J, Vaidyanathan G, Koumarianou E, McDougald D, Pruszynski M, Osada T, Lahoutte T, Lyerly HK, Zalutsky MR. N-Succinimidyl guanidinomethyl iodobenzoate protein radiohalogenation agents: influence of isomeric substitution on radiolabeling and target cell residualization Nucl Med Biol. 2014 Nov-Dec;41(10):802-12.
7: Allen KJH, Jiao R, Malo ME, Dadachova E. Evaluation of N-Succinimidyl S-Acetylthioacetate Ligand for Radiolabeling of Humanized Antibodies with (188)Rhenium Cancer Biother Radiopharm. 2018 Oct;33(8):349-355.
8: Garg PK, Archer GE Jr, Bigner DD, Zalutsky MR. Synthesis of radioiodinated N-succinimidyl iodobenzoate: optimization for use in antibody labelling Int J Rad Appl Instrum A. 1989;40(6):485-90.
9: Kim HK, Javed MR, Chen S, Zettlitz KA, Collins J, Wu AM, Kim CCJ, Michael van Dam R, Keng PY. On-demand radiosynthesis of N-succinimidyl-4-[(18)F]fluorobenzoate ([(18)F]SFB) on an electrowetting-on-dielectric microfluidic chip for (18)F-labeling of protein RSC Adv. 2019 Oct 9;9(55):32175-32183.
10: Garg PK, Garg S, Zalutsky MR. N-succinimidyl 4-methyl-3-(tri-n-butylstannyl)benzoate: synthesis and potential utility for the radioiodination of monoclonal antibodies Nucl Med Biol. 1993 May;20(4):379-87.

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