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Human VEGF-C (Recombinant and Highly Pure)

$695.00 $495.00

Catalog Number: B2010374 (10 ug)
Human VEGF-C (Highly Pure) is a high quality research product used as highly pure Human VEGF-C (Highly Pure) expressed in HEK 293. This protein acts as a protein involved in lymphangiogenesis whereby it acts on lymphatic endothelial cells (LECs) primarily via its receptor VEGFR-3 promoting survival, growth and migration. Custom bulk orders of this product are available upon request.

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SKU: B2010374 Categories: , ,

Description

Human VEGF-C (Highly Pure)
Catalog number: B2010374
Lot number: Batch Dependent
Expiration Date: Batch dependent
Volume/Weight: 10 ug
pH: 7.4 upon reconstitution
Supplied as: Lyophilized Powder
Appearance: Powder
Applications: highly pure Human VEGF-C (Highly Pure) expressed in HEK 293. This protein acts as a protein involved in lymphangiogenesis whereby it acts on lymphatic endothelial cells (LECs) primarily via its receptor VEGFR-3 promoting survival, growth and migration.
Storage: -20C
Keywords: rHuVEGF-C; Vascular endothelial growth factor C; Flt4-L; VRP
Grade: Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Song E, Mao T, Dong H, Boisserand LSB, Antila S, Bosenberg M, Alitalo K,
Thomas JL, Iwasaki A. VEGF-C-driven lymphatic drainage enables
immunosurveillance of brain tumours. Nature. 2020 Jan;577(7792):689-694.

2: Su CM, Tang CH, Chi MJ, Lin CY, Fong YC, Liu YC, Chen WC, Wang SW. Resistin
facilitates VEGF-C-associated lymphangiogenesis by inhibiting miR-186 in human
chondrosarcoma cells. Biochem Pharmacol. 2018 Aug;154:234-242.

3: Li WN, Hsiao KY, Wang CA, Chang N, Hsu PL, Sun CH, Wu SR, Wu MH, Tsai SJ.
Extracellular vesicle-associated VEGF-C promotes lymphangiogenesis and immune
cells infiltration in endometriosis. Proc Natl Acad Sci U S A. 2020 Oct
13;117(41):25859-25868.

4: Schwager S, Detmar M. Inflammation and Lymphatic Function. Front Immunol.
2019 Feb 26;10:308.

5: Cheng MX, Li JZ, Chen Y, Cao D, Gong JP, Tu B. VEGF-C attenuates ischemia
reperfusion injury of liver graft in rats. Transpl Immunol. 2019 Jun;54:59-64.

6: Yang ZS, Xu YF, Huang FF, Ding GF. Associations of nm23H1, VEGF-C, and VEGF-3
receptor in human prostate cancer. Molecules. 2014 May 23;19(5):6851-62.

7: Miao H, Ruan S, Shen M. VEGF-C in rectal cancer tissues promotes tumor
invasion and metastasis. J BUON. 2018 Jan-Feb;23(1):42-47.

8: Wang LH, Lin CY, Liu SC, Liu GT, Chen YL, Chen JJ, Chan CH, Lin TY, Chen CK,
Xu GH, Chen SS, Tang CH, Wang SW. CCL5 promotes VEGF-C production and induces
lymphangiogenesis by suppressing miR-507 in human chondrosarcoma cells.
Oncotarget. 2016 Jun 14;7(24):36896-36908.
9: Michaelsen SR, Staberg M, Pedersen H, Jensen KE, Majewski W, Broholm H,
Nedergaard MK, Meulengracht C, Urup T, Villingshøj M, Lukacova S, Skjøth-
Rasmussen J, Brennum J, Kjær A, Lassen U, Stockhausen MT, Poulsen HS, Hamerlik
P. VEGF-C sustains VEGFR2 activation under bevacizumab therapy and promotes
glioblastoma maintenance. Neuro Oncol. 2018 Oct 9;20(11):1462-1474.

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