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Tyrosine Kinase Receptor A (Human)

$695.00 $495.00

Catalog Number: B2010372 (10 ug)
Human Tyrosine kinase receptor A is a high quality research product used as highly pure Human Tyrosine kinase receptor A expressed in HEK 293. This protein acts as a high affinity catalytic receptor for neurotrophin and nerve growth factor (NGF). It also mediates the multiple effects of NGF, which include neuronal differentiation and avoidance of programmed cell death. Custom bulk orders of this product are available upon request.

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SKU: B2010372 Categories: , ,

Description

Tyrosine kinase receptor A
Catalog number: B2010372
Lot number: Batch Dependent
Expiration Date: Batch dependent
Volume/Weight: 10 ug
pH: 7.4 upon reconstitution
Supplied as: Lyophilized Powder
Appearance: Powder
Applications: highly pure Human Tyrosine kinase receptor A expressed in HEK 293. This protein acts as a high affinity catalytic receptor for neurotrophin and nerve growth factor (NGF). It also mediates the multiple effects of NGF, which include neuronal differentiation and avoidance of programmed cell death.
Storage: -20C
Keywords: rHuTrkA; NTRK1; MTC; TRK
Grade: Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Du Z, Lovly CM. Mechanisms of receptor tyrosine_kinase activation in cancer.
Mol Cancer. 2018 Feb 19;17(1):58.

2: Trenker R, Jura N. Receptor_tyrosine kinase activation: From the ligand
perspective. Curr Opin Cell Biol. 2020 Apr;63:174-185.

3: Hallberg B, Palmer RH. Mechanistic insight into ALK receptor tyrosine kinase
in human cancer biology. Nat Rev Cancer. 2013 Oct;13(10):685-700.
24060861.

4: Hallberg B, Palmer RH. The role of the ALK receptor in cancer biology. Ann
Oncol. 2016 Sep;27 Suppl 3:iii4-iii15.

5: Linger RM, Keating AK, Earp HS, Graham DK. TAM receptor tyrosine_kinases:
biologic functions, signaling, and potential therapeutic targeting in human
cancer. Adv Cancer Res. 2008;100:35-83.

6: Nakada M, Kita D, Teng L, Pyko IV, Watanabe T, Hayashi Y, Hamada JI. Receptor
Tyrosine Kinases: Principles and Functions in Glioma Invasion. Adv Exp Med Biol.
2020;1202:151-178.

7: Sun ZG, Liu JH, Zhang JM, Qian Y. Research Progress of Axl Inhibitors. Curr
Top Med Chem. 2019;19(15):1338-1349.

8: Biarc J, Chalkley RJ, Burlingame AL, Bradshaw RA. Receptor tyrosine_kinase
signaling–a proteomic perspective. Adv Enzyme Regul. 2011;51(1):293-305.

9: Dengjel J, Kratchmarova I, Blagoev B. Receptor tyrosine kinase signaling: a
view from quantitative proteomics. Mol Biosyst. 2009 Oct;5(10):1112-21.

Products Related to Human Tyrosine kinase receptor A : Proteins

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