Trefoil Factor-3 (Human Recombinant)

Description

Human Trefoil Factor-3
Catalog number: B2010371
Lot number: Batch Dependent
Expiration Date: Batch dependent
Volume/Weight: 10 ug
pH: 7.4 upon reconstitution
Supplied as: Lyophilized Powder
Appearance: Powder
Applications: highly pure Human Trefoil Factor-3 expressed in E. coli. This protein acts as a regulatory peptide involved in mucosal protection and repair in the gastrointestinal tract.
Storage: -20C
Keywords: rHuTFF-3; ITF; TFI
Grade: Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Griffin BR, Faubel S, Edelstein CL. Biomarkers of Drug-Induced Kidney
Toxicity. Ther Drug Monit. 2019 Apr;41(2):213-226.

2: Popp J, Schicht M, Garreis F, Klinger P, Gelse K, Sesselmann S, Tsokos M,
Etzold S, Stiller D, Claassen H, Paulsen F. Human Synovia Contains Trefoil
Factor Family (TFF) Peptides 1-3 Although Synovial Membrane Only Produces TFF3:
Implications in Osteoarthritis and Rheumatoid Arthritis. Int J Mol Sci. 2019 Dec
3;20(23):6105.

3: Fitzgerald RC, di Pietro M, O’Donovan M, Maroni R, Muldrew B, Debiram-Beecham
I, Gehrung M, Offman J, Tripathi M, Smith SG, Aigret B, Walter FM, Rubin G;
BEST3 Trial team, Sasieni P. Cytosponge-trefoil factor 3 versus usual care to
identify Barrett’s oesophagus in a primary care setting: a multicentre,
pragmatic, randomised controlled trial. Lancet. 2020 Aug 1;396(10247):333-344.

4: Krüger K, Schmid S, Paulsen F, Ignatius A, Klinger P, Hotfiel T, Swoboda B,
Gelse K. Trefoil Factor 3 (TFF3) Is Involved in Cell Migration for Skeletal
Repair. Int J Mol Sci. 2019 Sep 1;20(17):4277.

5: Sun Y, Wang L, Zhou Y, Mao X, Deng X. Human Trefoil Factor 3 induces the
transcription of its own promoter through STAT3. Sci Rep. 2016 Jul 25;6:30421.

6: Li Q, Wang K, Su C, Fang J. Serum Trefoil Factor 3 as a Protein Biomarker for
the Diagnosis of Colorectal Cancer. Technol Cancer Res Treat. 2017
Aug;16(4):440-445.

7: Zhang Z. Trefoil factor 3 knock-down prevents autophagy-related gene 12
elevation in colon adenocarcinoma. J Histotechnol. 2019 Dec;42(4):169-176.

8: Nakov R, Velikova T, Nakov V, Gerova V, Tankova L. Trefoil Factor 3 is Highly
Predictive of Complete Mucosal Healing Independently and in Combination with
C-Reactive Protein in Patients with Ulcerative Colitis. J Gastrointestin Liver
Dis. 2019 Jun 1;28:169-174.

9: Hoffmann W. Trefoil Factor Family (TFF) Peptides and Their Diverse Molecular
Functions in Mucus Barrier Protection and More: Changing the Paradigm. Int J Mol
Sci. 2020 Jun 25;21(12):4535.

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