Human High Oxidized Low Density Lipoprotein
Original price was: $1,595.00.$795.00Current price is: $795.00.
Catalog Number: B2027101 (1 mg)
Human High Oxidized Low Density Lipoprotein is a chemically modified lipoprotein prepared from human plasma LDL that has undergone extensive oxidative modification of its lipid and apolipoprotein B components. This extensively oxidized lipoprotein exhibits a strong net negative charge, making it structurally distinct from native LDL and a specific ligand for macrophage scavenger receptors. Custom bulk amounts of this product are available upon request.
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Product Description
Human High Oxidized Low Density Lipoprotein
Catalog number: B2027101
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 1 mg
Molecular Weight or Concentration: NA
Supplied as: Solution
Storage: 2-8°C
Keywords: Oxidized LDL, oxLDL, low density lipoprotein, human protein, lipid research, cellular uptake, scavenger receptor, foam cell formation, endocytosis, oxidative stress, apolipoprotein B-100, lipid peroxidation
References:
1. Goldstein, J. L., Ho, Y. K., Basu, S. K., & Brown, M. S. (1979). Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition. Proceedings of the National Academy of Sciences, 76(1), 333-337.
2. Pitas, R. E., Boyles, J., Mahley, R. W., & Bissell, D. M. (1985). Uptake of chemically modified low density lipoproteins in vivo is mediated by specific endothelial cells. Journal of Cell Biology, 100(1), 103-117.
3. Sparrow, C. P., Parthasarathy, S., & Steinberg, D. (1989). A macrophage receptor that recognizes oxidized low density lipoprotein but not acetylated low density lipoprotein. Journal of Biological Chemistry, 264(5), 2599-2604.
4. Kume, N., Arai, H., Kawai, C., & Kita, T. (1991). Receptors for modified low-density lipoproteins on human endothelial cells: different mechanisms for uptake of acetylated and oxidized low-density lipoproteins. Journal of Clinical Investigation, 88(3), 995-1002.
5. Krieger, M., & Herz, J. (1994). Structures and functions of scavenger receptors. Annual Review of Biochemistry, 63, 601-637.
6. Nagayama, M., Arai, H., Kita, T., & Oho, S. (1994). Differences in the metabolism of oxidatively modified low density lipoprotein and acetylated low density lipoprotein by human endothelial cells. Biochemical and Biophysical Research Communications, 202(1), 405-411.
7. Lougheed, M., Moore, E. D., & Gase, J. C. (1997). Uptake and degradation of acetylated low density lipoprotein by human vascular endothelial cells via high-affinity binding. Arteriosclerosis, Thrombosis, and Vascular Biology, 17(4), 721-729.
8. Tintut, Y., Patel, J., Parhami, F., & Demer, L. L. (2002). Acetylated low-density lipoprotein stimulates human vascular smooth muscle cell calcification by promoting osteoblastic differentiation and inhibiting phagocytosis. Circulation, 106(21), 2711-2717.
9. Poznyak, A. V., Nikiforov, N. G., Starodubova, A. V., Popkova, T. V., & Orekhov, A. N. (2021). Oxidized LDL receptor 1 (LOX-1) as a therapeutic target in atherosclerosis. International Journal of Molecular Sciences, 22(10), 5053.
10. Falih, I. Q., Hussein, M. A., & Al-Bayati, M. A. (2021). The role of low-density lipoprotein (LDL-C) and oxidized LDL in the pathogenesis of cardiovascular diseases. Journal of Chemical Health Risks, 11, 71-83.
Human High Oxidized Low Density Lipoprotein
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Additional Information
| Weight | 0.15 oz |
|---|---|
| Dimensions | 2 × 0.5 × 0.5 in |
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