Human gAcrp30/Adipolean (Highly Pure)


Catalog Number: B2010379 (10 ug)
Human gAcrp30/Adipolean is a high quality research product used as highly pure Human gAcrp30/Adipolean expressed in E. coli. This protein acts as the globular head group of adiponectin, regulates fatty acid and glucose metabolism. Custom bulk orders of this product are available upon request.

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SKU: B2010379 Categories: ,


Human gAcrp30/Adipolean
Catalog number: B2010379
Lot number: Batch Dependent
Expiration Date: Batch dependent
Volume/Weight: 10 ug
pH: 7.4 upon reconstitution
Supplied as: Lyophilized Powder
Appearance: Powder
Applications: highly pure Human gAcrp30/Adipolean expressed in E. coli. This protein acts as the globular head group of adiponectin, regulates fatty acid and glucose metabolism.
Storage: -20C
Keywords: rHugAcrp30/Adipolean; Adiponectin; ACRP30; APM-1; ADIPOQ; ACDC
Grade: Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

1: Li X, Zhang D, Vatner DF, Goedeke L, Hirabara SM, Zhang Y, Perry RJ, Shulman
GI. Mechanisms by which adiponectin reverses high fat diet-induced insulin
resistance in mice. Proc Natl Acad Sci U S A. 2020 Dec 22;117(51):32584-32593.

2: Chedid P, Hurtado-Nedelec M, Marion-Gaber B, Bournier O, Hayem G, Gougerot-
Pocidalo MA, Frystyk J, Flyvbjerg A, El Benna J, Marie JC. Adiponectin and its
globular fragment differentially modulate the oxidative burst of primary human
phagocytes. Am J Pathol. 2012 Feb;180(2):682-92.

3: Rakatzi I, Mueller H, Ritzeler O, Tennagels N, Eckel J. Adiponectin
counteracts cytokine- and fatty acid-induced apoptosis in the pancreatic beta-
cell line INS-1. Diabetologia. 2004 Feb;47(2):249-58.

4: Tomas E, Tsao TS, Saha AK, Murrey HE, Zhang Cc Cc, Itani SI, Lodish HF,
Ruderman NB. Enhanced muscle fat oxidation and glucose transport by ACRP30
globular domain: acetyl-CoA carboxylase inhibition and AMP-activated protein
kinase activation. Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):16309-13.

5: Dietze-Schroeder D, Sell H, Uhlig M, Koenen M, Eckel J. Autocrine action of
adiponectin on human fat cells prevents the release of insulin resistance-
inducing factors. Diabetes. 2005 Jul;54(7):2003-11.

6: Bruce CR, Mertz VA, Heigenhauser GJ, Dyck DJ. The stimulatory effect of
globular adiponectin on insulin-stimulated glucose uptake and fatty acid
oxidation is impaired in skeletal muscle from obese subjects. Diabetes. 2005

7: Fruebis J, Tsao TS, Javorschi S, Ebbets-Reed D, Erickson MR, Yen FT, Bihain
BE, Lodish HF. Proteolytic cleavage product of 30-kDa adipocyte complement-
related protein increases fatty acid oxidation in muscle and causes weight loss
in mice. Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):2005-10.

8: Tsao TS, Murrey HE, Hug C, Lee DH, Lodish HF. Oligomerization state-dependent
activation of NF-kappa B signaling pathway by adipocyte complement-related
protein of 30 kDa (Acrp30). J Biol Chem. 2002 Aug 16;277(33):29359-62.
9: Hu XB, Zhang YJ, Zhang HT, Yang SL, Gong Y. Cloning and expression of
adiponectin and its globular domain, and measurement of the biological activity
in vivo. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 2003

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