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Fibroblast Growth Factor-19 (Human)

$695.00 $495.00

Catalog Number: B2010359 (10 ug)
Human Fibroblast Growth Factor-19 is a high quality research product used as highly pure Human Fibroblast Growth Factor-19 expressed in E. coli. This protein acts as a protein that could activate a physiologically important, insulin-independent endocrine pathway that regulates hepatic protein and glycogen metabolism. Custom bulk orders of this product are available upon request.

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SKU: B2010359 Categories: , ,

Description

Human Fibroblast Growth Factor-19
Catalog number: B2010359
Lot number: Batch Dependent
Expiration Date: Batch dependent
Volume/Weight: 10 ug
pH: 7.4 upon reconstitution
Supplied as: Lyophilized Powder
Appearance: Powder
Applications: highly pure Human Fibroblast Growth Factor-19 expressed in E. coli. This protein acts as a protein that could activate a physiologically important, insulin-independent endocrine pathway that regulates hepatic protein and glycogen metabolism.
Storage: -20C
Keywords: rHuFGF-19; FGF19
Grade: Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Benoit B, Meugnier E, Castelli M, Chanon S, Vieille-Marchiset A, Durand C,
Bendridi N, Pesenti S, Monternier PA, Durieux AC, Freyssenet D, Rieusset J,
Lefai E, Vidal H, Ruzzin J. Fibroblast growth factor 19 regulates skeletal
muscle mass and ameliorates muscle wasting in mice. Nat Med. 2017
Aug;23(8):990-996.

2: Gadaleta RM, Garcia-Irigoyen O, Cariello M, Scialpi N, Peres C, Vetrano S,
Fiorino G, Danese S, Ko B, Luo J, Porru E, Roda A, Sabbà C, Moschetta A.
Fibroblast Growth Factor 19 modulates intestinal microbiota and inflammation in
presence of Farnesoid X Receptor. EBioMedicine. 2020 Apr;54:102719.

3: Chen H, Li J, Zhang D, Zhou X, Xie J. Role of the fibroblast growth factor 19
in the skeletal system. Life Sci. 2021 Jan 15;265:118804.

4: Kim YC, Byun S, Seok S, Guo G, Xu HE, Kemper B, Kemper JK. Small Heterodimer
Partner and Fibroblast Growth Factor 19 Inhibit Expression of NPC1L1 in Mouse
Intestine and Cholesterol Absorption. Gastroenterology. 2019
Mar;156(4):1052-1065.

5: Maeda T, Kanzaki H, Chiba T, Ao J, Kanayama K, Maruta S, Kusakabe Y, Saito T,
Kobayashi K, Kiyono S, Nakamura M, Ogasawara S, Suzuki E, Ooka Y, Nakamoto S,
Nakagawa R, Muroyama R, Kanda T, Maruyama H, Kato N. Serum fibroblast growth
factor 19 serves as a potential novel biomarker for hepatocellular carcinoma.
BMC Cancer. 2019 Nov 12;19(1):1088.

6: Guo A, Li K, Xiao Q. Fibroblast growth factor 19 alleviates palmitic acid-
induced mitochondrial dysfunction and oxidative stress via the AMPK/PGC-1α
pathway in skeletal muscle. Biochem Biophys Res Commun. 2020 Jun
11;526(4):1069-1076.

7: Chen J, Du F, Dang Y, Li X, Qian M, Feng W, Qiao C, Fan D, Nie Y, Wu K, Xia
L. Fibroblast Growth Factor 19-Mediated Up-regulation of SYR-Related High-
Mobility Group Box 18 Promotes Hepatocellular Carcinoma Metastasis by
Transactivating Fibroblast Growth Factor Receptor 4 and Fms-Related Tyrosine
Kinase 4. Hepatology. 2020 May;71(5):1712-1731.

8: Raja A, Park I, Haq F, Ahn SM. FGF19-FGFR4 Signaling in Hepatocellular
Carcinoma. Cells. 2019 Jun 4;8(6):536.

9: Rysz J, Gluba-Brzózka A, Mikhailidis DP, Banach M. Fibroblast growth factor
19-targeted therapies for the treatment of metabolic disease. Expert Opin
Investig Drugs. 2015 May;24(5):603-10.
10: Huang HH, Lee WJ, Chen SC, Chen TF, Lee SD, Chen CY. Bile Acid and
Fibroblast Growth Factor 19 Regulation in Obese Diabetics, and Non-Alcoholic
Fatty Liver Disease after Sleeve Gastrectomy. J Clin Med. 2019 Jun 7;8(6):815.

Products Related to Human Fibroblast Growth Factor-19 : Proteins

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