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Human Fibroblast Growth Factor 18

$495.00

Catalog Number: B2010337 (10 ug)
Human Fibroblast Growth Factor 18 is a high quality research product used as highly pure Human Fibroblast Growth Factor 18 expressed in E. coli. This protein acts as a heparin-binding polypeptide growth factor, involved in cartilage growth, maturation and the development of functional cartilage and bone tissue. Custom bulk orders of this product are available upon request.

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SKU: B2010337 Categories: , ,

Description

Human Fibroblast Growth Factor 18
Catalog number: B2010337
Lot number: Batch Dependent
Expiration Date: Batch dependent
Volume/Weight: 10 ug
pH: 7.4 upon reconstitution
Supplied as: Lyophilized Powder
Appearance: Powder
Applications: highly pure Human Fibroblast Growth Factor 18 expressed in E. coli. This protein acts as a heparin-binding polypeptide growth factor, involved in cartilage growth, maturation and the development of functional cartilage and bone tissue.
Storage: -20C
Keywords: rHuFGF-18; zFGF5; FGF18
Grade: Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Xie Y, Zinkle A, Chen L, Mohammadi M. Fibroblast growth factor signalling in
osteoarthritis and cartilage repair. Nat Rev Rheumatol. 2020 Oct;16(10):547-564.

2: Häckel S, Zolfaghar M, Du J, Hoppe S, Benneker LM, Garstka N, Peroglio M,
Alini M, Grad S, Yayon A, Li Z. Fibrin-Hyaluronic Acid Hydrogel (RegenoGel) with
Fibroblast Growth Factor-18 for In Vitro 3D Culture of Human and Bovine Nucleus
Pulposus Cells. Int J Mol Sci. 2019 Oct 11;20(20):5036.

3: Yu Z, Lou L, Zhao Y. Fibroblast growth factor 18 promotes the growth,
migration and invasion of MDA‑MB‑231 cells. Oncol Rep. 2018 Aug;40(2):704-714.

4: Zhang W, Robertson WB, Zhao J, Chen W, Xu J. Emerging Trend in the
Pharmacotherapy of Osteoarthritis. Front Endocrinol (Lausanne). 2019 Jul
2;10:431.

5: Tachmazidou I, Hatzikotoulas K, Southam L, Esparza-Gordillo J, Haberland V,
Zheng J, Johnson T, Koprulu M, Zengini E, Steinberg J, Wilkinson JM, Bhatnagar
S, Hoffman JD, Buchan N, Süveges D; arcOGEN Consortium, Yerges-Armstrong L,
Smith GD, Gaunt TR, Scott RA, McCarthy LC, Zeggini E. Identification of new
therapeutic targets for osteoarthritis through genome-wide analyses of UK
Biobank data. Nat Genet. 2019 Feb;51(2):230-236.

6: Hu MC, Wang YP, Qiu WR. Human fibroblast growth factor-18 stimulates
fibroblast cell proliferation and is mapped to chromosome 14p11. Oncogene. 1999
Apr 22;18(16):2635-42.

7: Ellman MB, Yan D, Ahmadinia K, Chen D, An HS, Im HJ. Fibroblast growth factor
control of cartilage homeostasis. J Cell Biochem. 2013 Apr;114(4):735-42.

8: Koneczny I, Schulenburg A, Hudec X, Knöfler M, Holzmann K, Piazza G, Reynolds
R, Valent P, Marian B. Autocrine fibroblast growth factor 18 signaling mediates
Wnt-dependent stimulation of CD44-positive human colorectal adenoma cells. Mol
Carcinog. 2015 Sep;54(9):789-799.

9: Yamaoka H, Nishizawa S, Asawa Y, Fujihara Y, Ogasawara T, Yamaoka K, Nagata
S, Takato T, Hoshi K. Involvement of fibroblast growth factor 18 in
dedifferentiation of cultured human chondrocytes. Cell Prolif. 2010
Feb;43(1):67-76.
10: Chen T, Gong W, Tian H, Wang H, Chu S, Ma J, Yang H, Cheng J, Liu M, Li X,
Jiang C. Fibroblast growth factor 18 promotes proliferation and migration of
H460 cells via the ERK and p38 signaling pathways. Oncol Rep. 2017
Feb;37(2):1235-1242.

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