Human Chorionic Gonadotropin Nicked Beta Subunit


Catalog Number: B2010656 (0.5 nmol)
Human Chorionic Gonadotropin Nicked Beta Subunit is a highly pure nicked form of the β-subunit of human chorionic gonadotrophin without
other forms of human chorionic gonadotrophin (such as hCG, α and β subunits). This product has been used as molecular tool in the research and development of hCG assays. It has also been used in a wide array of other biochemical and immunological applications. Custom bulk amounts of this product are available upon request.

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SKU: B2010656 Categories: ,


Human Chorionic Gonadotropin Nicked Beta Subunit
Catalog number: B2010656
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 0.5 nmol
Molecular Weight or Concentration: na
Supplied as: Lyophilized
Applications: molecular tool in the research and development of hCG assays
Storage: -20C
Keywords: nicked hCG
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

1: Cole LA. The hCG assay or pregnancy test. Clin Chem Lab Med. 2012

2: Sakakibara R, Miyazaki S, Ishiguro M. A nicked beta-subunit of human
chorionic gonadotropin purified from pregnancy urine. J Biochem. 1990

3: Montagnana M, Trenti T, Aloe R, Cervellin G, Lippi G. Human chorionic
gonadotropin in pregnancy diagnostics. Clin Chim Acta. 2011 Aug
4: Cole LA, Laidler LL. Inherited human chorionic gonadotropin. J Reprod Med.
2010 Mar-Apr;55(3-4):99-102.

5: Bidart JM, Troalen F, Lazar V, Berger P, Marcillac I, Lhomme C, Droz JP,
Bellet D. Monoclonal antibodies to the free beta-subunit of human chorionic
gonadotropin define three distinct antigenic domains and distinguish between
intact and nicked molecules. Endocrinology. 1992 Oct;131(4):1832-40.

6: Kardana A, Cole LA. Human chorionic gonadotropin beta-subunit nicking enzymes
in pregnancy and cancer patient serum. J Clin Endocrinol Metab. 1994

7: Cole LA, Kardana A, Ying FC, Birken S. The biological and clinical
significance of nicks in human chorionic gonadotropin and its free beta-subunit.
Yale J Biol Med. 1991 Nov-Dec;64(6):627-37.

8: Birken S, Chen Y, Gawinowicz MA, Lustbader JW, Pollak S, Agosto G, Buck R,
O’Connor J. Separation of nicked human chorionic gonadotropin (hCG), intact hCG,
and hCG beta fragment from standard reference preparations and raw urine
samples. Endocrinology. 1993 Sep;133(3):1390-7.

9: Rotmensch S, Liberati M, Kardana A, Copel JA, Ben-Rafael Z, Cole LA. Nicked
free beta-subunit of human chorionic gonadotropin: a potential new marker for
Down syndrome screening. Am J Obstet Gynecol. 1996 Feb;174(2):609-11.
10: Yoshimura M, Pekary AE, Pang XP, Berg L, Cole LA, Kardana A, Hershman JM.
Effect of peptide nicking in the human chorionic gonadotropin beta-subunit on
stimulation of recombinant human thyroid-stimulating hormone receptors. Eur J
Endocrinol. 1994 Jan;130(1):92-6.

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